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Details on Person Corepressors are released from liganded PPARG:RXRA heterodimer

Class:IdReaction:9843117
_displayNameCorepressors are released from liganded PPARG:RXRA heterodimer
_doReleaseTRUE
_timestamp2025-11-10 19:43:08
authored[InstanceEdit:9843123] Orlic-Milacic, Marija, 2023-08-31
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9843123] Orlic-Milacic, Marija, 2023-08-31
edited[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
input[DefinedSet:9851465] PPARG ligands:PPARG:RXRA ligands:RXRA:Corepressors:adipogenesis genes:Nucleosomes [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9918754] May, Bruce, 2024-08-17
[InstanceEdit:9919312] Matthews, Lisa, 2024-08-21
[InstanceEdit:9927587] May, Bruce, 2024-03-08
[InstanceEdit:9928383] Matthews, Lisa, 2024-11-15
isChimericFALSE
literatureReference[LiteratureReference:9860045] Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma
[LiteratureReference:9860333] FK614, a novel peroxisome proliferator-activated receptor gamma modulator, induces differential transactivation through a unique ligand-specific interaction with transcriptional coactivators
[LiteratureReference:9860705] L312, a novel PPARĪ³ ligand with potent anti-diabetic activity by selective regulation
modified[InstanceEdit:9851478] Orlic-Milacic, Marija, 2023-10-26
[InstanceEdit:9851504] Orlic-Milacic, Marija, 2023-10-26
[InstanceEdit:9860051] Orlic-Milacic, Marija, 2024-01-29
[InstanceEdit:9860054] Orlic-Milacic, Marija, 2024-01-29
[InstanceEdit:9860340] Orlic-Milacic, Marija, 2024-02-02
[InstanceEdit:9860708] Orlic-Milacic, Marija, 2024-02-10
[InstanceEdit:9907517] Orlic-Milacic, Marija, 2024-04-11
[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
[InstanceEdit:9917571] Orlic-Milacic, Marija, 2024-08-07
[InstanceEdit:9918755] Orlic-Milacic, Marija, 2024-08-17
[InstanceEdit:9919218] Orlic-Milacic, Marija, 2024-08-19
[InstanceEdit:9919313] Matthews, Lisa, 2024-08-21
[InstanceEdit:9927588] Matthews, Lisa, 2024-11-08
[InstanceEdit:9928382] Matthews, Lisa, 2024-11-15
[InstanceEdit:9970997] Orlic-Milacic, Marija, 2025-11-04
[InstanceEdit:9971757] Orlic-Milacic, Marija, 2025-11-10
[InstanceEdit:9971761] Orlic-Milacic, Marija, 2025-11-10
nameCorepressors are released from liganded PPARG:RXRA heterodimer
output[DefinedSet:9851475] PPARG ligands:PPARG:RXRA ligands:RXRA:adipogenesis genes:Nucleosomes [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
[DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2024-09-11
reviewed[InstanceEdit:9971758] Khag, Joy, 2025-10-31
[InstanceEdit:9971759] Wang, Shu-Ping, 2025-10-31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9843128] R-HSA-9843117.3
structureModified[InstanceEdit:9851478] Orlic-Milacic, Marija, 2023-10-26
[InstanceEdit:9918755] Orlic-Milacic, Marija, 2024-08-17
[InstanceEdit:9971757] Orlic-Milacic, Marija, 2025-11-10
summation[Summation:9860053] Binding of activator ligands to the PPARG:RXRA dimer causes ...
(hasEvent)[Pathway:9841922] MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9843120] Coactivators are recruited to liganded PPARG:RXRA heterodimer [Homo sapiens]
(updatedInstance)[_UpdateTracker:9971845] Update Tracker - [Reaction:9843117] Corepressors are released from liganded PPARG:RXRA heterodimer - v95:[modifyText]
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No pathways have been reviewed or authored by Corepressors are released from liganded PPARG:RXRA heterodimer (9843117)
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