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Details on Person PPARG2 transcription is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex

Class:Id	BlackBoxEvent:9843116
_displayName	PPARG2 transcription is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex
_doRelease	TRUE
_timestamp	2025-11-04 05:14:02
authored	[InstanceEdit:9843123] Orlic-Milacic, Marija, 2023-08-31
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9843123] Orlic-Milacic, Marija, 2023-08-31
edited	[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
inferredFrom	[BlackBoxEvent:9856352] Pparg2 transcription is stimulated by Pparg2 and Mll4 complex [Mus musculus]
input	[EntityWithAccessionedSequence:5640205] PPARG gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9907495] May, Bruce, 2024-04-10
isChimeric	FALSE
modified	[InstanceEdit:9851504] Orlic-Milacic, Marija, 2023-10-26 [InstanceEdit:9851523] Orlic-Milacic, Marija, 2023-10-26 [InstanceEdit:9851527] Orlic-Milacic, Marija, 2023-10-26 [InstanceEdit:9856251] Orlic-Milacic, Marija, 2023-12-14 [InstanceEdit:9856355] Orlic-Milacic, Marija, 2023-12-18 [InstanceEdit:9859514] Orlic-Milacic, Marija, 2024-01-20 [InstanceEdit:9859584] Orlic-Milacic, Marija, 2024-01-21 [InstanceEdit:9907287] Orlic-Milacic, Marija, 2024-04-05 [InstanceEdit:9907517] Orlic-Milacic, Marija, 2024-04-11 [InstanceEdit:9907535] Orlic-Milacic, Marija, 2024-04-12 [InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9917571] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9919218] Orlic-Milacic, Marija, 2024-08-19 [InstanceEdit:9971050] Orlic-Milacic, Marija, 2025-11-04
name	PPARG2 transcription is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex
output	[DefinedSet:9856246] PPARG1,PPARG2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9843121] MLL4-ASCOM, (MLL3-ASCOM) complex monomethylates nucleosomes at PPARG:RXRA-bound enhancers [Homo sapiens] [Reaction:9843119] MLL4-ASCOM,(MLL3-ASCOM) complex is recruited to ligand- and coactivator-bound PPARG:RXRA heterodimer [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9851526] Positive gene expression regulation by 'Activated PPARG:RXRA:PPARG gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm]'
releaseDate	2024-09-11
reviewed	[InstanceEdit:9970975] Aberin, Marvin Angelo E, 2025-10-31 [InstanceEdit:9970978] Wang, Shu-Ping, 2025-10-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9843125] R-HSA-9843116.2
structureModified	[InstanceEdit:9851523] Orlic-Milacic, Marija, 2023-10-26 [InstanceEdit:9851527] Orlic-Milacic, Marija, 2023-10-26
summation	[Summation:9856247] Based on mouse studies, expression of the PPARG2 isoform of ...
(hasEvent)	[Pathway:9841922] MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9971898] Update Tracker - [BlackBoxEvent:9843116] PPARG2 transcription is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex - v95:[modifyText]
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No pathways have been reviewed or authored by PPARG2 transcription is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex (9843116)