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Details on Person GOCAM CSN2 gene expression is stimulated by ERBB4s80:STAT5A

Class:Id	BlackBoxEvent:9842898
_displayName	GOCAM CSN2 gene expression is stimulated by ERBB4s80:STAT5A
_doRelease	FALSE
_timestamp	2023-10-06 20:28:50
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9842920] D'Eustachio, Peter, 2023-08-29
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
input	[EntityWithAccessionedSequence:8954222] CSN2 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1254286] The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone [LiteratureReference:1254297] Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation [LiteratureReference:2029515] ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo
modified	[InstanceEdit:9842975] D'Eustachio, Peter, 2023-08-29 [InstanceEdit:9842979] D'Eustachio, Peter, 2023-08-29 [InstanceEdit:9843359] D'Eustachio, Peter, 2023-09-07 [InstanceEdit:9845638] D'Eustachio, Peter, 2023-10-06
name	GOCAM CSN2 gene expression is stimulated by ERBB4s80:STAT5A
output	[EntityWithAccessionedSequence:1254293] CSN2 [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:9842903] GOCAM ERBB4s80:STAT5A binds CSN2 gene promoter [Homo sapiens] [Reaction:9842925] GOCAM ERBB4s80:STAT5A complex translocates to the nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:1254289] Positive gene expression regulation by 'ERBB4s80:p-Y694-STAT5A:CSN2 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641564] Positive gene expression regulation by 'ERBB4s80:p-Y694-STAT5A:CSN2 gene [nucleoplasm]' The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9842956] R-HSA-9842898.1
summation	[Summation:1254282] ERBB4s80:STAT5A complex binds to and stimulates transcriptio...
(hasEvent)	[Pathway:9842908] GOCAM Nuclear signaling by ERBB4 [Homo sapiens]
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No pathways have been reviewed or authored by GOCAM CSN2 gene expression is stimulated by ERBB4s80:STAT5A (9842898)