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Details on Person ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin

Class:Id	Reaction:9842839
_displayName	ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin
_doRelease	TRUE
_timestamp	2024-05-14 13:32:50
authored	[InstanceEdit:9842857] May, Bruce, 2023-08-26
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9842827] May, Bruce, 2023-08-29
edited	[InstanceEdit:9842857] May, Bruce, 2023-08-26
input	[Complex:9842852] SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] [Homo sapiens] [Complex:5159246] ATF7IP:SETDB1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9842875] NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression [LiteratureReference:5173305] SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins [LiteratureReference:3301890] mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression [LiteratureReference:9843630] Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP
modified	[InstanceEdit:9843688] May, Bruce, 2023-09-08 [InstanceEdit:9851264] May, Bruce, 2023-10-15 [InstanceEdit:9856776] May, Bruce, 2023-12-23 [InstanceEdit:9909823] May, Bruce, 2024-05-14
name	ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin
output	[Complex:9842840] ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9842868] TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2 [Homo sapiens] [Reaction:9842850] TRIM28 (KAP1) binds KRAB-ZFP in KRAB-ZFP:retroelement chromatin [Homo sapiens]
releaseDate	2024-06-15
reviewed	[InstanceEdit:9909738] Bourc'his, Deborah, 2024-05-14 [InstanceEdit:9909756] Fernandes, Liane P, 2024-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9842892] R-HSA-9842839.1
summation	[Summation:9843622] SETDB1 binds the C-terminal region of TRIM28 (KAP1) which co...
(hasEvent)	[Pathway:9843940] Regulation of endogenous retroelements by KRAB-ZFP proteins [Homo sapiens]
(precedingEvent)	[Reaction:9842833] SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes [Homo sapiens]
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No pathways have been reviewed or authored by ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (9842839)