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Details on Person Active LTK binds IRS1

Class:Id	Reaction:9842671
_displayName	Active LTK binds IRS1
_doRelease	TRUE
_timestamp	2024-03-04 17:21:02
authored	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9842653] Rothfels, Karen, 2023-08-27
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
input	[Complex:9842590] p-5Y LTK dimer:ALKAL1,2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:74769] IRS1 [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9843214] Orlic-Milacic, Marija, 2023-09-06
isChimeric	FALSE
literatureReference	[LiteratureReference:9842507] An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway [LiteratureReference:9842473] Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase [LiteratureReference:9842415] Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice [LiteratureReference:9842439] Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth [LiteratureReference:9842463] MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening [LiteratureReference:9842429] ALK-activating homologous mutations in LTK induce cellular transformation
modified	[InstanceEdit:9845040] Rothfels, Karen, 2023-09-26 [InstanceEdit:9851737] Rothfels, Karen, 2023-10-30 [InstanceEdit:9852938] Rothfels, Karen, 2023-11-08 [InstanceEdit:9852942] Rothfels, Karen, 2023-11-08 [InstanceEdit:9862075] Rothfels, Karen, 2024-02-22 [InstanceEdit:9863616] Rothfels, Karen, 2024-03-04
name	Active LTK binds IRS1
output	[Complex:9842600] Active LTK:IRS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9842648] Autophosphorylation of LTK dimer:ALKAL1,2 [Homo sapiens] [Reaction:9842660] LTK binds ALKAL ligand [Homo sapiens]
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9842675] R-HSA-9842671.1
summation	[Summation:9842643] MAPK phosphorylation is observed downstream of both activate...
(hasEvent)	[Pathway:9842663] Signaling by LTK [Homo sapiens]
(precedingEvent)	[Reaction:9842666] Active LTK phosphorylates IRS1 [Homo sapiens]
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No pathways have been reviewed or authored by Active LTK binds IRS1 (9842671)