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Details on Person LTK binds ALKAL ligand

Class:IdReaction:9842660
_displayNameLTK binds ALKAL ligand
_doReleaseTRUE
_timestamp2024-02-22 20:21:05
authored[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
compartment[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:9842653] Rothfels, Karen, 2023-08-27
edited[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
input[EntityWithAccessionedSequence:9842564] LTK [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9842564] LTK [plasma membrane] [Homo sapiens]
[DefinedSet:9842609] ALKAL1,2 [extracellular region] [Homo sapiens]
internalReviewed[InstanceEdit:9843214] Orlic-Milacic, Marija, 2023-09-06
isChimericFALSE
literatureReference[LiteratureReference:9842427] The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase
[LiteratureReference:9842439] Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth
[LiteratureReference:9842437] Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome
[LiteratureReference:9842539] FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase
[LiteratureReference:9842433] Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions
[LiteratureReference:9842490] Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α)
[LiteratureReference:9842445] Mechanism for the activation of the anaplastic lymphoma kinase receptor
[LiteratureReference:9842419] Structural basis of cytokine-mediated activation of ALK family receptors
modified[InstanceEdit:9851737] Rothfels, Karen, 2023-10-30
[InstanceEdit:9852940] Rothfels, Karen, 2023-11-08
[InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
[InstanceEdit:9862075] Rothfels, Karen, 2024-02-22
nameLTK binds ALKAL ligand
output[Complex:9842594] LTK dimer:ALKAL1,2 [plasma membrane] [Homo sapiens]
releaseDate2024-03-27
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9842676] R-HSA-9842660.1
summation[Summation:9842645] Leukocyte tyrosine kinase (LTK) receptor is a member of the ...
(hasEvent)[Pathway:9842663] Signaling by LTK [Homo sapiens]
(precedingEvent)[Reaction:9842648] Autophosphorylation of LTK dimer:ALKAL1,2 [Homo sapiens]
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