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Details on Person SIRT3 deacetylates Ac-K272,K290-FOXO3

Class:Id	Reaction:9841847
_displayName	SIRT3 deacetylates Ac-K272,K290-FOXO3
_doRelease	TRUE
_timestamp	2024-11-12 23:56:27
authored	[InstanceEdit:9841260] May, Bruce, 2023-08-11
catalystActivity	[CatalystActivity:9841872] protein lysine deacetylase activity of SIRT3(?-399) [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9841861] May, Bruce, 2023-08-15
edited	[InstanceEdit:9841260] May, Bruce, 2023-08-11
input	[EntityWithAccessionedSequence:9841849] Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] [Homo sapiens] [SimpleEntity:113526] NAD+ [mitochondrial matrix] [SimpleEntity:113526] NAD+ [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix]
internalReviewed	[InstanceEdit:9858315] Matthews, Lisa, 2024-01-11 [InstanceEdit:9919312] Matthews, Lisa, 2024-08-21 [InstanceEdit:9863722] Matthews, Lisa, 2024-03-05
isChimeric	FALSE
literatureReference	[LiteratureReference:9622894] SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage [LiteratureReference:9841855] SIRT3 interactions with FOXO3 acetylation, phosphorylation and ubiquitinylation mediate endothelial cell responses to hypoxia [LiteratureReference:9841865] SirT3 regulates the mitochondrial unfolded protein response
modified	[InstanceEdit:9841947] May, Bruce, 2023-08-16 [InstanceEdit:9859421] May, Bruce, 2024-01-19 [InstanceEdit:9918121] May, Bruce, 2024-08-14 [InstanceEdit:9919313] Matthews, Lisa, 2024-08-21 [InstanceEdit:9928230] Matthews, Lisa, 2024-11-12
name	SIRT3 deacetylates Ac-K272,K290-FOXO3
output	[EntityWithAccessionedSequence:9841824] FOXO3(?-673) [mitochondrial matrix] [Homo sapiens] [SimpleEntity:5688337] 2'-O-acetyl-ADP-ribose [mitochondrial matrix] [SimpleEntity:5688337] 2'-O-acetyl-ADP-ribose [mitochondrial matrix]
releaseDate	2024-09-11
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9841877] R-HSA-9841847.2
structureModified	[InstanceEdit:9859421] May, Bruce, 2024-01-19
summation	[Summation:9841937] In response to unfolded protein in the mitochondrial interme...
(hasEvent)	[Pathway:9841251] Mitochondrial unfolded protein response (UPRmt) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9841812] FOXO3 translocates from the mitochondrial matrix to the nucleus [Homo sapiens]
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No pathways have been reviewed or authored by SIRT3 deacetylates Ac-K272,K290-FOXO3 (9841847)