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Details on Person UniProt:O16616 trim-21
| Class:Id | ReferenceGeneProduct:9841286 |
|---|---|
| _chainChangeLog | chain:1-292 for 9841286 added on Fri August 11 2023 |
| _displayName | UniProt:O16616 trim-21 |
| _timestamp | 2023-11-03 15:41:46 |
| chain | chain:1-292 |
| checksum | DF40855A856D49B7 |
| comment | FUNCTION E3 ubiquitin-protein ligase which catalyzes 'Lys-48'-linked polyubiquitination of ced-1, promoting its proteasomal degradation to maintain appropriate ced-1 levels for apoptotic cell clearance (PubMed:35929733). Acts together with E2 ubiquitin-conjugating enzyme ubc-21 (PubMed:35929733).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with E2 ubiquitin-conjugating enzyme ubc-21 (PubMed:35929733). Interacts with ced-6; this mediates interaction of trim-21 with ced-1 and is required for ced-1 ubiquitination (PubMed:35929733). Interacts with nck-1; the interaction is required for ced-1 ubiquitination (PubMed:35929733).SUBCELLULAR LOCATION In early larva, observed mainly in pharyngeal and body wall muscle cells.DOMAIN The coiled coil is required for interactions with ced-1, ced-6 and ubc-21.DISRUPTION PHENOTYPE RNAi-mediated knockdown results in increased levels of ced-1.SIMILARITY Belongs to the TRIM/RBCC family. |
| created | [InstanceEdit:9841277] Weiser, Joel |
| description | recommendedName: fullName evidence="5"E3 ubiquitin-protein ligase trim-21 ecNumber evidence="4"2.3.2.27 |
| geneName | trim-21 B0281.8 |
| identifier | O16616 |
| isSequenceChanged | FALSE |
| keyword | Coiled coil Cytoplasm Metal-binding Reference proteome Transferase Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | trim-21 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TRI21_CAEEL |
| sequenceLength | 292 |
| species | [Species:68320] Caenorhabditis elegans |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O16616 trim-21 (9841286)
