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Details on Person UniProt:D3YZZ2 Tgfbr3l
| Class:Id | ReferenceGeneProduct:9841285 |
|---|---|
| _chainChangeLog | signal peptide:1-17 for 9841285 added on Fri August 11 2023;chain:18-297 for 9841285 added on Fri August 11 2023 |
| _displayName | UniProt:D3YZZ2 Tgfbr3l |
| _timestamp | 2023-11-03 15:12:58 |
| chain | signal peptide:1-17 chain:18-297 |
| checksum | B6E144B736B8434C |
| comment | FUNCTION Expressed in gonadotrope cells, acts as an inhibin B coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility.SUBCELLULAR LOCATION Expressed in pituitary gland gonadotrope cells.PTM Glycosylated.DISRUPTION PHENOTYPE Females show no effects on puberty onset, estrous cyclicity and body weight. They have increased litter sizes relative to wild-type with normal litter frequency. Females ovulate more eggs in natural cycles with increased uterine implantation sites. They have increased numbers of antral follicles and corpora lutea (PubMed:34910520). Double knockout females for TGFBR3L and gonadotrope-specific TGFBR3 are infertile. They have increased serum follicle-stimulating hormone (FSH), pituitary protein content relative to controls. They have larger ovaries with increased numbers of antral follicles and corpora lutea (PubMed:34910520). |
| created | [InstanceEdit:9841277] Weiser, Joel |
| description | recommendedName: Transforming growth factor-beta receptor type 3-like protein alternativeName: TGF-beta receptor type-3-like protein shortName: TGFR-3L alternativeName: Transforming growth factor, beta receptor III-like |
| geneName | Tgfbr3l Gm14378 |
| identifier | D3YZZ2 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Disulfide bond Membrane Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Tgfbr3l |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TGR3L_MOUSE |
| sequenceLength | 297 |
| species | [Species:48892] Mus musculus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:D3YZZ2 Tgfbr3l (9841285)
