Query author contributions in Reactome
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Details on Person OBOX, a PRD-like homeobox domain TF family (OBOX1-8), are ke...
| Class:Id | Summation:9841104 |
|---|---|
| _displayName | OBOX, a PRD-like homeobox domain TF family (OBOX1-8), are ke... |
| _timestamp | 2023-08-08 22:51:04 |
| created | [InstanceEdit:9841091] May, Bruce, 2023-08-08 |
| text | OBOX, a PRD-like homeobox domain TF family (OBOX1-8), are key regulators of mouse ZGA. Mice deficient for maternally-transcribed Obox1/2/5/7 and zygotically-expressed Obox3/4 had a 2-4 cell arrest accompanied by impaired ZGA. Both maternal and zygotic OBOX can bind promoters and/or enhancers of MERVL, Zscan4, Dppa2/3/4, and Nr5a2 in mouse early embryos (Ji et al., 2023). Near 50% of ZGA genes including Zscan4, Dppa4, Nr5a2 were downregulated in 2-cell embryos after knocking out maternal and zygotic Obox. Ectopic expression of OBOX activated a subset of ZGA genes including Dppa4, Gata1/4, Trim43a/b/c, and MERVL repeats in mESCs. |
| (summation) | [Reaction:9841076] Obox1,2,3,4,5,6,7,8 binds Zscan4a,d [Mus musculus] |
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No pathways have been reviewed or authored by OBOX, a PRD-like homeobox domain TF family (OBOX1-8), are ke... (9841104)
