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Details on Person UniProt:Q8VHG5 Obox4
| Class:Id | ReferenceGeneProduct:9841102 |
|---|---|
| _chainChangeLog | chain:1-380 for 9841102 added on Mon Feb 26 2024 |
| _displayName | UniProt:Q8VHG5 Obox4 |
| _timestamp | 2024-05-14 17:30:17 |
| chain | chain:1-380 |
| checksum | 5D9EBB8FB8EBB312 |
| comment | FUNCTION Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Cannot compensate for loss of other members of the Obox family, suggesting that its function differs from other Obox family members (PubMed:37459895). May regulate expression of histone genes in embryonic stem cells (PubMed:20004198). Also involved in completion of meiosis of oocytes during the meiosis-I/meiosis-II transition (PubMed:20154267, PubMed:22384421). Required to maintain the nuclear membrane of the germinal vesicle in oocytes (PubMed:26762402).SUBCELLULAR LOCATION Nuclear localization is dependent on its homeobox domain.TISSUE SPECIFICITY Specifically expressed in early embryos.DEVELOPMENTAL STAGE Expression is low in oocytes (PubMed:37459895). Expressed zygotically with expression peaking in early-two-cell stage embryos, during minor zygotic genome activation (ZGA), and declining in late two-cell stage embryos (PubMed:37459895).DISRUPTION PHENOTYPE No visible phenotype; mice are viable and fertile (PubMed:37459895). Female mice lacking maternally transcribed Obox1, Obox2, Obox5, Obox7 as well as zygotically expressed Obox3 and Obox4 are infertile: embryos arrest at two-four cell stage due to impaired zygotic genome activation (ZGA) (PubMed:37459895).SIMILARITY Belongs to the paired homeobox family. Obox subfamily. |
| created | [InstanceEdit:9841091] May, Bruce, 2023-08-08 |
| description | recommendedName: fullName evidence="10"Oocyte-specific homeobox protein 4 |
| geneName | Obox4 |
| identifier | Q8VHG5 |
| isSequenceChanged | FALSE |
| keyword | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 |
| name | Obox4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | OBOX4_MOUSE |
| sequenceLength | 380 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9841093] Obox4 [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q8VHG5 Obox4 (9841102)
