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Details on Person bHEXA,bHEXS hydrolyze GM2A:SM2

Class:IdReaction:9840884
_displayNamebHEXA,bHEXS hydrolyze GM2A:SM2
_doReleaseTRUE
_timestamp2025-01-29 09:16:38
authored[InstanceEdit:9840856] Stephan, Ralf, 2023-07-30
catalystActivity[CatalystActivity:9840888] beta-N-acetylhexosaminidase activity of bHEXA,bHEXS [lysosomal lumen]
compartment[Compartment:161320] lysosomal lumen
created[InstanceEdit:9840892] Stephan, Ralf, 2023-08-01
edited[InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
input[Complex:9840882] GM2A:SM2 [lysosomal lumen] [Homo sapiens]
[SimpleEntity:1605715] H2O [lysosomal lumen]
isChimericFALSE
literatureReference[LiteratureReference:9840889] Physiological substrates for human lysosomal beta -hexosaminidase S
modified[InstanceEdit:9840953] Stephan, Ralf, 2023-08-02
[InstanceEdit:9840955] Stephan, Ralf, 2023-08-02
[InstanceEdit:9842097] Stephan, Ralf, 2023-08-17
[InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
namebHEXA,bHEXS hydrolyze GM2A:SM2
output[SimpleEntity:1605658] GalNAc [lysosomal lumen]
[SimpleEntity:9840879] SM3 [lysosomal lumen]
[EntityWithAccessionedSequence:1605614] GM2A(32-193) [lysosomal lumen] [Homo sapiens]
precedingEvent
regulatedBy[Requirement:9840876] Requirement by 'BMP [multivesicular body, internal vesicle membrane]'
regulationReference[RegulationReference:9840877] Requirement by 'BMP [multivesicular body, internal vesicle membrane]' Physiological substrates for human lysosomal beta -hexosaminidase S
releaseDate2023-09-13
reviewed[InstanceEdit:9842059] D'Eustachio, Peter, 2023-08-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9840898] R-HSA-9840884.2
structureModified[InstanceEdit:9840953] Stephan, Ralf, 2023-08-02
summation[Summation:9840887] The beta-hexosaminidase isoforms A (bHEXA) and S (bHEXS) con...
(hasEvent)[Pathway:9840310] Glycosphingolipid catabolism [Homo sapiens]
(precedingEvent)[Reaction:1605717] GM2A binds and mobilizes ligands [Homo sapiens]
[Reaction:9840949] ARSA removes sulfate from SM3 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9853261] Update Tracker - [Reaction:9840884] bHEXA,bHEXS hydrolyze GM2A:SM2 - v87:[modifyText]
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