Query author contributions in Reactome
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Details on Person Ganglioside GA2 (asialo-GM2, ganglio-N-triaosylceramide), bo...
| Class:Id | Summation:9840836 |
|---|---|
| _displayName | Ganglioside GA2 (asialo-GM2, ganglio-N-triaosylceramide), bo... |
| _timestamp | 2023-08-27 07:19:26 |
| created | [InstanceEdit:9840838] Stephan, Ralf, 2023-07-29 |
| modified | [InstanceEdit:9842382] Stephan, Ralf, 2023-08-27 |
| text | Ganglioside GA2 (asialo-GM2, ganglio-N-triaosylceramide), bound to GM2A, gets cleaved by the beta-hexosaminidase complexes A and B. It is present at elevated levels in nerve cells in Sandhoff disease (Tay-Sachs disease variant O, MIM: 268800), a hexosaminidase beta subunit (HEXB) deficiency, which leads to low levels of both bHEX complexes bHEXA and bHEXB (Sandhoff et al., 1971; reviewed in Sandhoff et al., 2018; Sandhoff & Sandhoff, 2018). |
| (summation) | [Reaction:9840833] bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer [Homo sapiens] |
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No pathways have been reviewed or authored by Ganglioside GA2 (asialo-GM2, ganglio-N-triaosylceramide), bo... (9840836)
