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Details on Person bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer

Class:Id	Reaction:9840833
_displayName	bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer
_doRelease	TRUE
_timestamp	2025-01-29 09:16:29
authored	[InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
catalystActivity	[CatalystActivity:1605761] beta-N-acetylhexosaminidase activity of bHEXA,bHEXB [lysosomal lumen]
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9840838] Stephan, Ralf, 2023-07-29
edited	[InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
input	[SimpleEntity:1605715] H2O [lysosomal lumen] [Complex:9840792] GM2A:GA2 [lysosomal lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9840835] Enzyme alterations and lipid storage in three variants of Tay-Sachs disease [LiteratureReference:9840311] Ganglioside Metabolism in Health and Disease [LiteratureReference:9840312] Emerging concepts of ganglioside metabolism
modified	[InstanceEdit:9842097] Stephan, Ralf, 2023-08-17 [InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
name	bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer
output	[SimpleEntity:1605658] GalNAc [lysosomal lumen] [Complex:9840837] GM2A:LacCer [lysosomal lumen] [Homo sapiens]
precedingEvent	[Reaction:9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 [Homo sapiens] [Reaction:1605717] GM2A binds and mobilizes ligands [Homo sapiens]
releaseDate	2023-09-13
reviewed	[InstanceEdit:9842059] D'Eustachio, Peter, 2023-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9840840] R-HSA-9840833.2
summation	[Summation:9840836] Ganglioside GA2 (asialo-GM2, ganglio-N-triaosylceramide), bo...
(hasEvent)	[Pathway:9840310] Glycosphingolipid catabolism [Homo sapiens]
(precedingEvent)	[Reaction:1606312] GLB1 hydrolyzes SapB/C:LacCer [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9853244] Update Tracker - [Reaction:9840833] bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer - v87:[modifyText]
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No pathways have been reviewed or authored by bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (9840833)