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Details on Person During PINK1:PRKN-mediated mitophagy, the autophagy receptor...
| Class:Id | Summation:9840808 |
|---|---|
| _displayName | During PINK1:PRKN-mediated mitophagy, the autophagy receptor... |
| _timestamp | 2023-10-13 20:32:20 |
| created | [InstanceEdit:9840809] Shamovsky, Veronica, 2023-07-28 |
| literatureReference | [LiteratureReference:9840353] Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy [LiteratureReference:5683899] Atg9 vesicles are an important membrane source during early steps of autophagosome formation [LiteratureReference:9840831] Emerging roles of ATG proteins and membrane lipids in autophagosome formation |
| modified | [InstanceEdit:9840832] Shamovsky, Veronica, 2023-07-28 [InstanceEdit:9851200] Shamovsky, Veronica, 2023-10-13 |
| text | During PINK1:PRKN-mediated mitophagy, the autophagy receptor optineurin (OPTN) forms a complex with the autophagy-related 9A (ATG9A) protein, a membrane-spanning protein that is recruited to the autophagosomal formation site (Yamamoto H et al., 2012; Yamano K et al., 2020). ATG9A localizes to the cytoplasmic single-membrane vesicles, termed ATG9 vesicles (Yamamoto H et al., 2012). OPTN recruits cytoplasmic ATG9A vesicles to damaged mitochondria (Yamano K et al., 2020), where these vesicles provide membrane contact sites delivering proteins and lipids during autophagosome formation (Yamamoto H et al., 2012; reviewed by Nishimura T & Tooze SA 2020). The leucine zipper domain of OPTN is required for the interaction with ATG9A (Yamano K et al., 2020). Disruptions of OPTN:ATG9A interaction inhibits mitophagy (Yamano K et al., 2020). Interactions between OPTN and other ATG proteins such as microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B or LC3) are implicated in autophagy. |
| (summation) | [Reaction:9840807] OPTN binds ATG9A [Homo sapiens] |
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No pathways have been reviewed or authored by During PINK1:PRKN-mediated mitophagy, the autophagy receptor... (9840808)
