Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person PSAP(195-273) dimer:PE binds and mobilizes ligands

Class:Id	Reaction:9840470
_displayName	PSAP(195-273) dimer:PE binds and mobilizes ligands
_doRelease	TRUE
_timestamp	2025-01-29 09:15:29
authored	[InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
catalystActivity	[CatalystActivity:9840712] sphingolipid activator protein activity of PSAP(195-273) dimer [lysosomal lumen]
compartment	[Compartment:161320] lysosomal lumen [Compartment:3828048] multivesicular body, internal vesicle membrane
created	[InstanceEdit:9840468] Stephan, Ralf, 2023-07-19
edited	[InstanceEdit:9842093] Stephan, Ralf, 2023-08-17 [InstanceEdit:9842112] Stephan, Ralf, 2023-08-18
input	[Complex:9842117] PSAP(195-273):PE [lysosomal lumen] [Homo sapiens] [DefinedSet:9842141] PSAP(195-273) ligands [multivesicular body, internal vesicle membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:9840460] Degradation of membrane-bound ganglioside GM1. Stimulation by bis(monoacylglycero)phosphate and the activator proteins SAP-B and GM2-AP [LiteratureReference:9840471] Crystal structure of saposin B reveals a dimeric shell for lipid binding [LiteratureReference:9840485] Glycosphingolipid specificity of the human sulfatide activator protein [LiteratureReference:9840312] Emerging concepts of ganglioside metabolism
modified	[InstanceEdit:9840713] Stephan, Ralf, 2023-07-25 [InstanceEdit:9840940] Stephan, Ralf, 2023-08-02 [InstanceEdit:9841793] Stephan, Ralf, 2023-08-12 [InstanceEdit:9842097] Stephan, Ralf, 2023-08-17 [InstanceEdit:9842114] Stephan, Ralf, 2023-08-18 [InstanceEdit:9842142] Stephan, Ralf, 2023-08-21 [InstanceEdit:9842210] Matthews, Lisa, 2023-08-22 [InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
name	PSAP(195-273) dimer:PE binds and mobilizes ligands
output	[Complex:9840472] PSAP(195-273):Ligands:PE [lysosomal lumen] [Homo sapiens]
precedingEvent	[Reaction:9842115] PSAP(195-273) dimer binds PE [Homo sapiens] [Reaction:9840488] PSAP(195-273) forms a dimer [Homo sapiens] [BlackBoxEvent:9840579] GM1 localizes to ILV membrane [Homo sapiens] [BlackBoxEvent:9840581] GM1 localizes to endosome membrane [Homo sapiens] [Reaction:1606807] ARSA removes sulfate from PSAP(195-273):Sulfatide [Homo sapiens] [Reaction:2248891] M6PR transports activated ARSA to the lysosome [Homo sapiens] [Reaction:9840470] PSAP(195-273) dimer:PE binds and mobilizes ligands [Homo sapiens] [Reaction:9841189] GLA hydrolyzes PSAP(195-273):Gal2Cer:PE [Homo sapiens] [Reaction:9840470] PSAP(195-273) dimer:PE binds and mobilizes ligands [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2023-09-13
reviewed	[InstanceEdit:9842207] D'Eustachio, Peter, 2023-08-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9840505] R-HSA-9840470.2
structureModified	[InstanceEdit:9842114] Stephan, Ralf, 2023-08-18
summation	[Summation:9840455] By encapsulating phosphatidylethanolamines (PE) of different...
(hasEvent)	[Pathway:9840310] Glycosphingolipid catabolism [Homo sapiens]
(precedingEvent)	[Reaction:1605624] Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 [Homo sapiens] [Reaction:1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE [Homo sapiens] [Reaction:1605724] NEU1,4 hydrolyze PSAP(195-273):GM3:PE [Homo sapiens] [Reaction:1606807] ARSA removes sulfate from PSAP(195-273):Sulfatide [Homo sapiens] [Reaction:9841189] GLA hydrolyzes PSAP(195-273):Gal2Cer:PE [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by PSAP(195-273) dimer:PE binds and mobilizes ligands (9840470)