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Details on Person DELE1(143-515) binds EIF2AK1 (HRI)

Class:Id	Reaction:9840429
_displayName	DELE1(143-515) binds EIF2AK1 (HRI)
_doRelease	TRUE
_timestamp	2023-10-21 09:07:34
authored	[InstanceEdit:9840237] May, Bruce, 2023-07-14
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9840366] May, Bruce, 2023-07-18
edited	[InstanceEdit:9840237] May, Bruce, 2023-07-14
input	[EntityWithAccessionedSequence:9840380] DELE1(143-515) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9840380] DELE1(143-515) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9840380] DELE1(143-515) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9840380] DELE1(143-515) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9840380] DELE1(143-515) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9840380] DELE1(143-515) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9840380] DELE1(143-515) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9840380] DELE1(143-515) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9840382] EIF2AK1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9840367] A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol [LiteratureReference:9840412] Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway [LiteratureReference:9840417] The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer [LiteratureReference:9851301] DELE1 oligomerization promotes integrated stress response activation
modified	[InstanceEdit:9840666] May, Bruce, 2023-07-22 [InstanceEdit:9851305] May, Bruce, 2023-10-21 [InstanceEdit:9851308] May, Bruce, 2023-10-21
name	DELE1(143-515) binds EIF2AK1 (HRI)
output	[Complex:9840385] DELE1(143-515):EIF2AK1 [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9840401] DELE1(143-515) is released into the cytosol [Homo sapiens] [Reaction:9840408] OMA1 cleaves DELE1 [Homo sapiens]
releaseDate	2023-12-06
reviewed	[InstanceEdit:9851307] Guo, Xiaoyan, 2023-10-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9840439] R-HSA-9840429.1
structureModified	[InstanceEdit:9851305] May, Bruce, 2023-10-21
summation	[Summation:9840661] The C-terminal fragment of cleaved DELE1 interacts with EIF2...
(hasEvent)	[Pathway:9840373] Cellular response to mitochondrial stress [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9840415] DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) [Homo sapiens]
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