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Details on Person DELE1(143-515) is released into the cytosol

Class:Id	BlackBoxEvent:9840401
_displayName	DELE1(143-515) is released into the cytosol
_doRelease	TRUE
_timestamp	2023-10-21 09:07:52
authored	[InstanceEdit:9840237] May, Bruce, 2023-07-14
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:70101] cytosol
created	[InstanceEdit:9840366] May, Bruce, 2023-07-18
edited	[InstanceEdit:9840237] May, Bruce, 2023-07-14
input	[EntityWithAccessionedSequence:9840386] DELE1(143-515) [mitochondrial inner membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9840367] A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol [LiteratureReference:9840412] Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway [LiteratureReference:9840418] A mitochondrial iron-responsive pathway regulated by DELE1 [LiteratureReference:9840395] DELE1 tracks perturbed protein import and processing in human mitochondria
modified	[InstanceEdit:9840666] May, Bruce, 2023-07-22 [InstanceEdit:9851308] May, Bruce, 2023-10-21
name	DELE1(143-515) is released into the cytosol
output	[EntityWithAccessionedSequence:9840380] DELE1(143-515) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9840408] OMA1 cleaves DELE1 [Homo sapiens] [Reaction:9840532] OMA1 self-cleaves [Homo sapiens]
releaseDate	2023-12-06
reviewed	[InstanceEdit:9851307] Guo, Xiaoyan, 2023-10-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9840431] R-HSA-9840401.1
summation	[Summation:9840660] In unstressed mitochondria, DELE1 is completely imported int...
(hasEvent)	[Pathway:9840373] Cellular response to mitochondrial stress [Homo sapiens]
(precedingEvent)	[Reaction:9840429] DELE1(143-515) binds EIF2AK1 (HRI) [Homo sapiens]
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No pathways have been reviewed or authored by DELE1(143-515) is released into the cytosol (9840401)