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Details on Person PSAP is cleaved

Class:Id	BlackBoxEvent:9840334
_displayName	PSAP is cleaved
_doRelease	TRUE
_timestamp	2025-06-16 19:32:48
authored	[InstanceEdit:9840314] Stephan, Ralf, 2023-07-17
compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:9840326] Stephan, Ralf, 2023-07-17
edited	[InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
goBiologicalProcess	[GO_BiologicalProcess:6678] protein processing
input	[EntityWithAccessionedSequence:9840325] PSAP [lysosomal lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9840329] Lipid-binding proteins in membrane digestion, antigen presentation, and antimicrobial defense [LiteratureReference:9840327] A Comparative Study of Human Saposins [LiteratureReference:9840332] Molecular role of sulfated glycoprotein-1 (SGP-1/prosaposin) in Sertoli cells [LiteratureReference:9840335] Saposin proteins: structure, function, and role in human lysosomal storage disorders [LiteratureReference:9840694] Lysosomal degradation of membrane lipids [LiteratureReference:9840695] Proteolytic processing patterns of prosaposin in insect and mammalian cells [LiteratureReference:9840828] The precursor of sulfatide activator protein is processed to three different proteins
modified	[InstanceEdit:9840697] Stephan, Ralf, 2023-07-24 [InstanceEdit:9840815] Stephan, Ralf, 2023-07-28 [InstanceEdit:9842097] Stephan, Ralf, 2023-08-17 [InstanceEdit:9937069] Stephan, Ralf, 2025-01-29 [InstanceEdit:9956913] D'Eustachio, Peter, 2025-06-16
name	PSAP is cleaved
output	[EntityWithAccessionedSequence:9840336] PSAP(195-273) [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:1605602] PSAP(311-391) [lysosomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:9840328] PSAP(405-486) [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:351333] PSAP(60-142) [lysosomal lumen] [Homo sapiens]
releaseDate	2023-09-13
reviewed	[InstanceEdit:9842059] D'Eustachio, Peter, 2023-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9840340] R-HSA-9840334.3
summation	[Summation:9840330] After its transport to lysosomes, prosaposin (PSAP) gets cle...
(hasEvent)	[Pathway:9840310] Glycosphingolipid catabolism [Homo sapiens]
(precedingEvent)	[Reaction:1606564] GALC hydrolyzes GalCer [Homo sapiens] [Reaction:1606602] ASAH1 hydrolyzes ceramide [Homo sapiens] [Reaction:9840488] PSAP(195-273) forms a dimer [Homo sapiens]
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No pathways have been reviewed or authored by PSAP is cleaved (9840334)