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Details on Person YME1L1 degrades mitochondrial intermembrane space proteins

Class:Id	BlackBoxEvent:9839751
_displayName	YME1L1 degrades mitochondrial intermembrane space proteins
_doRelease	TRUE
_timestamp	2023-11-06 07:21:20
authored	[InstanceEdit:9839796] May, Bruce, 2023-07-09
catalystActivity	[CatalystActivity:9840193] ATP-dependent peptidase activity of YME1L1:substrate protein (mitochondrial intermembrane space) [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9839776] May, Bruce, 2023-07-10
edited	[InstanceEdit:9839796] May, Bruce, 2023-07-09
inferredFrom	[BlackBoxEvent:9839836] YME1 degrades TIM10 [Saccharomyces cerevisiae]
input	[Complex:9839792] YME1L1:substrate protein (mitochondrial intermembrane space) [mitochondrial inner membrane] [Homo sapiens] [SimpleEntity:5696069] ATP [mitochondrial intermembrane space] [SimpleEntity:189422] H2O [mitochondrial intermembrane space]
isChimeric	FALSE
literatureReference	[LiteratureReference:9839768] Lipid signalling drives proteolytic rewiring of mitochondria by YME1L [LiteratureReference:6801241] TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid [LiteratureReference:9839793] PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria [LiteratureReference:9852678] Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms
modified	[InstanceEdit:9839857] May, Bruce, 2023-07-10 [InstanceEdit:9840200] May, Bruce, 2023-07-13 [InstanceEdit:9852699] May, Bruce, 2023-11-06 [InstanceEdit:9852714] May, Bruce, 2023-11-06
name	YME1L1 degrades mitochondrial intermembrane space proteins
output	[Complex:9839129] YME1L1:Zn2+ hexamer [mitochondrial inner membrane] [Homo sapiens] [SimpleEntity:5696026] ADP [mitochondrial intermembrane space] [SimpleEntity:9839058] Pi [mitochondrial intermembrane space]
precedingEvent	[Reaction:9839772] YME1L1 binds mitochondrial intermembrane space proteins [Homo sapiens]
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852695] Aljghami, Mazen E, 2023-11-04 [InstanceEdit:9852696] Houry, Walid A, 2023-11-04 [InstanceEdit:9852693] Morey, Trevor, 2023-11-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9839803] R-HSA-9839751.1
structureModified	[InstanceEdit:9840200] May, Bruce, 2023-07-13
summation	[Summation:9839800] YME1L1 (YME1L, i-AAA) is a hexameric metalloprotease that is...
(hasEvent)	[Pathway:9837999] Mitochondrial protein degradation [Homo sapiens]
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No pathways have been reviewed or authored by YME1L1 degrades mitochondrial intermembrane space proteins (9839751)