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Details on Person TGFBR3, also known as betaglycan, is a member of the proteog...

Class:Id	Summation:9839404
_displayName	TGFBR3, also known as betaglycan, is a member of the proteog...
_timestamp	2024-02-22 14:15:34
created	[InstanceEdit:9839369] Tiwari, Krishna, 2023-07-05
literatureReference	[LiteratureReference:9840180] A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC [LiteratureReference:9840132] Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites [LiteratureReference:9840170] Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis [LiteratureReference:9840068] Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation. Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-beta [LiteratureReference:9840108] Betaglycan presents ligand to the TGF beta signaling receptor [LiteratureReference:9840155] Binding of two growth factor families to separate domains of the proteoglycan betaglycan [LiteratureReference:9840054] Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling [LiteratureReference:9840171] Inhibin is an antagonist of bone morphogenetic protein signaling [LiteratureReference:9840120] Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor-beta superfamily. Specialized binding regions for transforming growth factor-beta and inhibin A [LiteratureReference:9013341] Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop? [LiteratureReference:9013338] Structural investigation of the C-terminal catalytic fragment of presenilin 1 [LiteratureReference:9840092] The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior [LiteratureReference:9840110] The shedding of betaglycan is regulated by pervanadate and mediated by membrane type matrix metalloprotease-1 [LiteratureReference:9840174] The type III TGF-β receptor betaglycan transmembrane-cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease γ-secretase [LiteratureReference:9840062] Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma [LiteratureReference:9860115] Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations [LiteratureReference:9860109] Promoter Hypomethylation of TGFBR3 as a Risk Factor of Alzheimer's Disease: An Integrated Epigenomic-Transcriptomic Analysis [LiteratureReference:9860145] Role of glycosylation in TGF-β signaling and epithelial-to-mesenchymal transition in cancer
modified	[InstanceEdit:9860104] Tiwari, Krishna, 2024-01-31 [InstanceEdit:9861994] Tiwari, Krishna, 2024-02-22
text	TGFBR3, also known as betaglycan, is a member of the proteoglycan family (Zhang et al., 2020) and plays a key role in regulating TGF-beta receptor-mediated signaling (Esparza-Lopez et al., 2001, Blobe et al., 2001) as well as TGF-beta-independent signaling (Wiater et al.,2003, Andres et al., 1992). TGFBR3 is expressed in abundance in normal cells (Wang et al, 1991) and is known to be down-regulated in multiple cancers due to its function as a tumor suppressor (Zhang et al.,2020, Fang et al.,2020, Cook et al.,2019). TGFBR3 is a transmembrane protein but lacks kinase activity in its cytoplasmic domain (López-Casillas et al.,1991). TGFBR3 primarily works as a co-receptor for different signaling pathways and can either facilitate or inhibit them (Wiater et al.,2003, Andres et al., 1992, Esparza-Lopez et al., 2001). TGFBR3 binds to TGF-beta ligands, facilitates their presentation to the TGFBR2 receptor, and helps in complex formation between TGFBR2 and TGFBR1 (Esparza-Lopez et al., 2001, Blobe et al., 2001). TGFBR3 also facilitates FGF:FGFR receptor complex stability and functions in FGFR1-mediated signaling as a co-receptor (Andres et al., 1992). TGBFR3 regulates signaling by other TGF-beta family members, including BMP2/7 and Activin (Wiater et al.,2003). Thus, TGFBR3 is involved in normal cell signaling and plays an important role in cancer, inflammatory diseases (Santiago et al, 2020), and Alzheimer's (Song et al., 2022).
(summation)	[Pathway:9839373] Signaling by TGFBR3 [Homo sapiens]
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No pathways have been reviewed or authored by TGFBR3, also known as betaglycan, is a member of the proteog... (9839404)