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Details on Person TGFBR3_mem cleavage by MMPs

Class:IdReaction:9839367
_displayNameTGFBR3_mem cleavage by MMPs
_doReleaseTRUE
_timestamp2024-05-15 13:13:57
authored[InstanceEdit:9840908] Tiwari, Krishna, 2023-07-25
catalystActivity[CatalystActivity:1604361] serine-type endopeptidase activity of MMP14 (16) [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9839369] Tiwari, Krishna, 2023-07-05
edited[InstanceEdit:9840908] Tiwari, Krishna, 2023-07-25
input[EntityWithAccessionedSequence:9839336] TGFBR3_mem [plasma membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9853359] Orlic-Milacic, Marija, 2023-11-15
isChimericFALSE
literatureReference[LiteratureReference:9840110] The shedding of betaglycan is regulated by pervanadate and mediated by membrane type matrix metalloprotease-1
[LiteratureReference:9840132] Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites
modified[InstanceEdit:9840098] Tiwari, Krishna, 2023-07-13
[InstanceEdit:9840909] Tiwari, Krishna, 2023-08-01
[InstanceEdit:9861994] Tiwari, Krishna, 2024-02-22
[InstanceEdit:9910564] Tiwari, Krishna, 2024-05-15
nameTGFBR3_mem cleavage by MMPs
output[EntityWithAccessionedSequence:9839335] TGFBR3(21-851) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:9839380] TGFBR3(784-851) [basolateral plasma membrane] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:9839372] Negative regulation by 'TIMP1 [extracellular region]'
[NegativeRegulation:9839391] Negative regulation by 'TIMP2 [extracellular region]'
regulationReference[RegulationReference:9840163] Negative regulation by 'TIMP1 [extracellular region]' The shedding of betaglycan is regulated by pervanadate and mediated by membrane type matrix metalloprotease-1
[RegulationReference:9840083] Negative regulation by 'TIMP2 [extracellular region]' The shedding of betaglycan is regulated by pervanadate and mediated by membrane type matrix metalloprotease-1
releaseDate2024-06-15
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9839436] R-HSA-9839367.1
summation[Summation:9840091] MT1‑MMP and MT3‑MMP are responsible for the ectodomain shedd...
(hasEvent)[Pathway:9839383] TGFBR3 PTM regulation [Homo sapiens]
(precedingEvent)[Reaction:9839368] TGFBR3(1-783) binds to TGFB1,TGFB2 [Homo sapiens]
[BlackBoxEvent:9839376] TGFBR3(784-851) degradation [Homo sapiens]
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No pathways have been reviewed or authored by TGFBR3_mem cleavage by MMPs (9839367)
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