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Details on Person AFG3L2 binds mitochondrial matrix proteins

Class:Id	Reaction:9839149
_displayName	AFG3L2 binds mitochondrial matrix proteins
_doRelease	TRUE
_timestamp	2023-11-06 07:15:25
authored	[InstanceEdit:9838634] May, Bruce, 2023-06-23
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9839143] May, Bruce, 2023-06-30
edited	[InstanceEdit:9838634] May, Bruce, 2023-06-23
input	[Complex:9838620] AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] [Homo sapiens] [DefinedSet:9839078] Substrate of AFG3L2 (mitochondrial matrix) [mitochondrial matrix] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9838610] StAR enhances transcription of genes encoding the mitochondrial proteases involved in its own degradation [LiteratureReference:9838618] Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease [LiteratureReference:9839138] Loss of Mitochondrial AAA Proteases AFG3L2 and YME1L Impairs Mitochondrial Structure and Respiratory Chain Biogenesis [LiteratureReference:9838605] Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia [LiteratureReference:9839057] Dissecting Substrate Specificities of the Mitochondrial AFG3L2 Protease
modified	[InstanceEdit:9839714] May, Bruce, 2023-07-07 [InstanceEdit:9852699] May, Bruce, 2023-11-06 [InstanceEdit:9852714] May, Bruce, 2023-11-06
name	AFG3L2 binds mitochondrial matrix proteins
output	[Complex:9839083] AFG3L2:substrate protein (mitochondrial matrix) [mitochondrial inner membrane] [Homo sapiens]
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852695] Aljghami, Mazen E, 2023-11-04 [InstanceEdit:9852696] Houry, Walid A, 2023-11-04 [InstanceEdit:9852693] Morey, Trevor, 2023-11-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9839173] R-HSA-9839149.1
summation	[Summation:9839661] AFG3L2 (m-AAA+) is a hexameric zinc metalloprotease that is ...
(hasEvent)	[Pathway:9837999] Mitochondrial protein degradation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9839105] AFG3L2 degrades mitochondrial matrix proteins [Homo sapiens]
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No pathways have been reviewed or authored by AFG3L2 binds mitochondrial matrix proteins (9839149)