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Details on Person YME1L1 degrades mitochondrial inner membrane proteins

Class:Id	BlackBoxEvent:9839146
_displayName	YME1L1 degrades mitochondrial inner membrane proteins
_doRelease	TRUE
_timestamp	2023-11-06 07:21:03
authored	[InstanceEdit:9839136] May, Bruce, 2023-06-27
catalystActivity	[CatalystActivity:9840195] ATP-dependent peptidase activity of YME1L1:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9839143] May, Bruce, 2023-06-30
edited	[InstanceEdit:9839136] May, Bruce, 2023-06-27
inferredFrom	[BlackBoxEvent:9839836] YME1 degrades TIM10 [Saccharomyces cerevisiae]
input	[Complex:9839096] YME1L1:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] [Homo sapiens] [SimpleEntity:5696069] ATP [mitochondrial intermembrane space] [SimpleEntity:189422] H2O [mitochondrial intermembrane space]
isChimeric	FALSE
literatureReference	[LiteratureReference:9839070] Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress [LiteratureReference:9839132] Multiple genes, including a member of the AAA family, are essential for degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria [LiteratureReference:9839075] YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation [LiteratureReference:9839138] Loss of Mitochondrial AAA Proteases AFG3L2 and YME1L Impairs Mitochondrial Structure and Respiratory Chain Biogenesis [LiteratureReference:9839768] Lipid signalling drives proteolytic rewiring of mitochondria by YME1L
modified	[InstanceEdit:9839806] May, Bruce, 2023-07-10 [InstanceEdit:9839857] May, Bruce, 2023-07-10 [InstanceEdit:9840200] May, Bruce, 2023-07-13 [InstanceEdit:9852699] May, Bruce, 2023-11-06 [InstanceEdit:9852714] May, Bruce, 2023-11-06
name	YME1L1 degrades mitochondrial inner membrane proteins
output	[Complex:9839129] YME1L1:Zn2+ hexamer [mitochondrial inner membrane] [Homo sapiens] [SimpleEntity:5696026] ADP [mitochondrial intermembrane space] [SimpleEntity:9839058] Pi [mitochondrial intermembrane space]
precedingEvent	[Reaction:9839064] YME1L1 binds mitochondrial inner membrane proteins [Homo sapiens]
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852695] Aljghami, Mazen E, 2023-11-04 [InstanceEdit:9852696] Houry, Walid A, 2023-11-04 [InstanceEdit:9852693] Morey, Trevor, 2023-11-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9839155] R-HSA-9839146.1
structureModified	[InstanceEdit:9840200] May, Bruce, 2023-07-13
summation	[Summation:9839799] YME1L1 (YME1L, i-AAA) is a hexameric metalloprotease that is...
(hasEvent)	[Pathway:9837999] Mitochondrial protein degradation [Homo sapiens]
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