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Details on Person AFG3L2 degrades mitochondrial inner membrane proteins

Class:Id	BlackBoxEvent:9839113
_displayName	AFG3L2 degrades mitochondrial inner membrane proteins
_doRelease	TRUE
_timestamp	2023-11-06 07:15:42
authored	[InstanceEdit:9839136] May, Bruce, 2023-06-27
catalystActivity	[CatalystActivity:9840201] ATP-dependent peptidase activity of AFG3L2:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9839143] May, Bruce, 2023-06-30
edited	[InstanceEdit:9839136] May, Bruce, 2023-06-27
input	[Complex:9838615] AFG3L2:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] [Homo sapiens] [SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:113593] ATP [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:9839057] Dissecting Substrate Specificities of the Mitochondrial AFG3L2 Protease [LiteratureReference:9839138] Loss of Mitochondrial AAA Proteases AFG3L2 and YME1L Impairs Mitochondrial Structure and Respiratory Chain Biogenesis [LiteratureReference:9839107] Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness [LiteratureReference:9838605] Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia [LiteratureReference:9838618] Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease
modified	[InstanceEdit:9839714] May, Bruce, 2023-07-07 [InstanceEdit:9840203] May, Bruce, 2023-07-13 [InstanceEdit:9852699] May, Bruce, 2023-11-06 [InstanceEdit:9852714] May, Bruce, 2023-11-06
name	AFG3L2 degrades mitochondrial inner membrane proteins
output	[Complex:9838620] AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] [Homo sapiens] [SimpleEntity:113581] ADP [mitochondrial matrix] [SimpleEntity:113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:9838627] AFG3L2 binds mitochondrial inner membrane proteins [Homo sapiens]
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852695] Aljghami, Mazen E, 2023-11-04 [InstanceEdit:9852696] Houry, Walid A, 2023-11-04 [InstanceEdit:9852693] Morey, Trevor, 2023-11-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9839151] R-HSA-9839113.1
structureModified	[InstanceEdit:9840203] May, Bruce, 2023-07-13
summation	[Summation:9839685] AFG3L2 (m-AAA+) is a hexameric zinc metalloprotease that is ...
(hasEvent)	[Pathway:9837999] Mitochondrial protein degradation [Homo sapiens]
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No pathways have been reviewed or authored by AFG3L2 degrades mitochondrial inner membrane proteins (9839113)