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Details on Person AFG3L2 degrades mitochondrial matrix proteins

Class:IdBlackBoxEvent:9839105
_displayNameAFG3L2 degrades mitochondrial matrix proteins
_doReleaseTRUE
_timestamp2023-11-06 07:16:00
authored[InstanceEdit:9839136] May, Bruce, 2023-06-27
catalystActivity[CatalystActivity:9839139] ATP-dependent peptidase activity of AFG3L2:substrate protein (mitochondrial matrix) [mitochondrial inner membrane]
compartment[Compartment:70616] mitochondrial inner membrane
created[InstanceEdit:9839143] May, Bruce, 2023-06-30
edited[InstanceEdit:9839136] May, Bruce, 2023-06-27
input[Complex:9839083] AFG3L2:substrate protein (mitochondrial matrix) [mitochondrial inner membrane] [Homo sapiens]
[SimpleEntity:113593] ATP [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
isChimericFALSE
literatureReference[LiteratureReference:9839138] Loss of Mitochondrial AAA Proteases AFG3L2 and YME1L Impairs Mitochondrial Structure and Respiratory Chain Biogenesis
[LiteratureReference:9838610] StAR enhances transcription of genes encoding the mitochondrial proteases involved in its own degradation
[LiteratureReference:9838618] Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease
[LiteratureReference:9838605] Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia
[LiteratureReference:9839057] Dissecting Substrate Specificities of the Mitochondrial AFG3L2 Protease
[LiteratureReference:9838619] Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia
modified[InstanceEdit:9839714] May, Bruce, 2023-07-07
[InstanceEdit:9840200] May, Bruce, 2023-07-13
[InstanceEdit:9852699] May, Bruce, 2023-11-06
[InstanceEdit:9852714] May, Bruce, 2023-11-06
nameAFG3L2 degrades mitochondrial matrix proteins
output[Complex:9838620] AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] [Homo sapiens]
[SimpleEntity:113581] ADP [mitochondrial matrix]
[SimpleEntity:113548] Pi [mitochondrial matrix]
precedingEvent
releaseDate2023-12-06
reviewed[InstanceEdit:9852695] Aljghami, Mazen E, 2023-11-04
[InstanceEdit:9852696] Houry, Walid A, 2023-11-04
[InstanceEdit:9852693] Morey, Trevor, 2023-11-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9839164] R-HSA-9839105.1
structureModified[InstanceEdit:9840200] May, Bruce, 2023-07-13
summation[Summation:9839692] AFG3L2 (m-AAA+) is a hexameric zinc metalloprotease that is ...
(hasEvent)[Pathway:9837999] Mitochondrial protein degradation [Homo sapiens]
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