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Details on Person PKR binds viral dsRNA

Class:IdReaction:9839016
_displayNamePKR binds viral dsRNA
_doReleaseTRUE
_timestamp2025-01-29 09:14:20
authored[InstanceEdit:9841883] Stephan, Ralf, 2023-08-15
compartment[Compartment:70101] cytosol
created[InstanceEdit:9839011] Stephan, Ralf, 2023-06-29
disease[Disease:3134794] viral infectious disease
edited[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
input[EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens]
[DefinedSet:9839014] Viral RNA activators of PKR [cytosol] [Hepatitis C Virus]
isChimericFALSE
literatureReference[LiteratureReference:9833727] Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeast
[LiteratureReference:9833737] Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop
[LiteratureReference:9833767] Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
[LiteratureReference:9833536] The search for a PKR code-differential regulation of protein kinase R activity by diverse RNA and protein regulators
[LiteratureReference:9837125] IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation
[LiteratureReference:9841955] Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase
modified[InstanceEdit:9841795] Matthews, Lisa, 2023-08-14
[InstanceEdit:9841952] Stephan, Ralf, 2023-08-16
[InstanceEdit:9841967] Stephan, Ralf, 2023-08-16
[InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
namePKR binds viral dsRNA
output[Complex:9839013] EIF2AK2 dimer:Viral RNA activators [cytosol] [Homo sapiens]
regulatedBy[PositiveRegulation:9837122] Positive regulation by 'MAVS [mitochondrial outer membrane]'
regulationReference[RegulationReference:9837121] Positive regulation by 'MAVS [mitochondrial outer membrane]' IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation
releaseDate2023-09-13
reviewed[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9839019] R-HSA-9839016.2
summation[Summation:9839015] Viral dsRNA is the primary activator of PKR (EIF2AK2). dsRNA...
(hasEvent)[Pathway:9833482] PKR-mediated signaling [Homo sapiens]
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