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Details on Person The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

Class:Id	LiteratureReference:9838808
_displayName	The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
_timestamp	2023-06-26 17:12:51
author	[Person:9838799] Heo, Jin-Mi [Person:9687077] Ordureau, Alban [Person:8953635] Paulo, Joao A [Person:9677777] Rinehart, Jesse [Person:2859007] Harper, J Wade
created	[InstanceEdit:9838806] Shamovsky, Veronica, 2023-06-26
journal	Mol Cell
pages	7-20
pubMedIdentifier	26365381
title	The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
volume	60
year	2015
(literatureReference)	[Reaction:9824888] OPTN, TBK1 bind ubiquitinated MOM proteins [Homo sapiens] [Reaction:9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins [Homo sapiens] [Summation:5205639] This is the process of selective removal of damaged mitochon... [Summation:9840304] Damaged mitochondria are flagged by ubiquitin (Ub) chains th... [Summation:9840615] Upon mitochondrial damage, TANK-binding kinase 1 (TBK1) is r... [Summation:9840619] Damaged mitochondria are flagged by ubiquitin (Ub) chains co... [Summation:9840786] Optineurin (OPTN) is an ubiquitin (Ub)-binding adaptor prote...
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