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Details on Person UniProt:Q8NFJ6 PROKR2
| Class:Id | ReferenceGeneProduct:98387 |
|---|---|
| _chainChangeLog | chain:1-384 added on Fri February 6 2015 |
| _displayName | UniProt:Q8NFJ6 PROKR2 |
| _timestamp | 2023-11-03 15:10:52 |
| chain | chain:1-384 |
| checksum | 2D5BFA3655347B5E |
| comment | FUNCTION Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.SUBUNIT Homodimer.INTERACTION Expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary and brain.DISEASE The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in PROKR2 as well as in other HH-associated genes including KAL1, SEMA3A, PROK2, GNRH1 and FGFR1 (PubMed:17054399, PubMed:22927827, PubMed:23643382).SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: Prokineticin receptor 2 shortName: PK-R2 alternativeName: G-protein coupled receptor 73-like 1 alternativeName: G-protein coupled receptor I5E alternativeName: GPR73b alternativeName: GPRg2 |
| geneName | PROKR2 GPR73L1 PKR2 |
| identifier | Q8NFJ6 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Disease variant Disulfide bond G-protein coupled receptor Glycoprotein Hypogonadotropic hypogonadism Kallmann syndrome Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | PROKR2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990317] ENSEMBL:ENSG00000101292 PROKR2 [Homo sapiens] |
| secondaryIdentifier | PKR2_HUMAN A5JUU1 Q2M3C0 Q5TDY1 Q9NTT0 |
| sequenceLength | 384 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:444637] PROKR2 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8NFJ6 PROKR2 (98387)
