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Details on Person Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix]

Class:Id	DefinedSet:9837979
_displayName	Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix]
_timestamp	2024-01-04 01:19:50
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9837983] May, Bruce, 2023-06-21
hasMember	[EntityWithAccessionedSequence:70855] ACAD8 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:70796] ACADSB(52-432) [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:70838] ACAT1(35-427) [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:70968] ACO2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:5690045] ACOT2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:5696097] ALDH1B1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:71718] ALDH2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:452025] ARG2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:164575] ATP5F1A [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:164576] ATP5F1B [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:164577] ATP5F1C [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:70972] CS [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:6792584] DBT [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9838037] ECH1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:53376] ECI1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:189441] FECH [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:70980] FH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:70582] GLUD1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:71051] HADH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:56573] HMGCS2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:70831] HSD17B10 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:8878802] HSPA9 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:1299448] HSPD1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:379571] IARS2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:70977] MDH2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9012080] ME2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9839674] MRPL12 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9839664] MRPL32 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9839682] MRPS2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9839687] MRPS10 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:8933311] NADK2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:6788513] NDUFS1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:69981] OGDH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:74317] OXCT1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:8933301] OXSM [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:3323190] PCCB [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:69967] PDHB [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:1592222] TWNK [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:203944] PDK1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:1299450] PMPCA [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:1592217] SSBP1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9838092] STAR [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9838277] p-S55,S56,S61,S160-TFAM [mitochondrial matrix] [Homo sapiens]
literatureReference	[LiteratureReference:9838048] LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival [LiteratureReference:9837987] Cleavage site selection within a folded substrate by the ATP-dependent lon protease [LiteratureReference:9837969] Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism [LiteratureReference:9837996] LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease [LiteratureReference:9838307] Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease
modified	[InstanceEdit:9838350] May, Bruce, 2023-06-22 [InstanceEdit:9839174] May, Bruce, 2023-06-30 [InstanceEdit:9839297] May, Bruce, 2023-07-05 [InstanceEdit:9839714] May, Bruce, 2023-07-07 [InstanceEdit:9852692] May, Bruce, 2023-11-06 [InstanceEdit:9857291] May, Bruce, 2024-01-04
name	Substrate of LONP1 (mitochondrial matrix)
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9838109] R-HSA-9837979.2
(hasComponent)	[Complex:9837986] LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] [Homo sapiens]
(input)	[Reaction:9838093] LONP1 binds mitochondrial matrix proteins [Homo sapiens]
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