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Details on Person ISGylation of BECN1

Class:Id	Reaction:9837231
_displayName	ISGylation of BECN1
_doRelease	TRUE
_timestamp	2023-11-14 04:45:20
authored	[InstanceEdit:9837128] Stephan, Ralf, 2023-06-10
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9837235] Stephan, Ralf, 2023-06-11
disease	[Disease:9833927] respiratory syncytial virus infectious disease
edited	[InstanceEdit:9852986] Stephan, Ralf, 2023-11-09
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:1632841] BECN1 [cytosol] [Homo sapiens] [Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens] [Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9837233] Human Respiratory Syncytial Virus NS2 Protein Induces Autophagy by Modulating Beclin1 Protein Stabilization and ISGylation
modified	[InstanceEdit:9837832] Shamovsky, Veronica, 2023-06-20 [InstanceEdit:9850763] Orlic-Milacic, Marija, 2023-10-12 [InstanceEdit:9851885] Orlic-Milacic, Marija, 2023-11-01 [InstanceEdit:9852855] Orlic-Milacic, Marija, 2023-11-07 [InstanceEdit:9852992] Stephan, Ralf, 2023-11-09 [InstanceEdit:9853033] Shamovsky, Veronica, 2023-11-09 [InstanceEdit:9853090] Matthews, Lisa, 2023-11-14
name	ISGylation of BECN1
output	[SimpleEntity:76577] AMP [cytosol] [SimpleEntity:76577] AMP [cytosol] [CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens] [CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens] [SimpleEntity:111294] PPi [cytosol] [SimpleEntity:111294] PPi [cytosol] [EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens] [Complex:9853032] ISG15:BECN1 [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9828718] NS2 (1B) mRNA is translated into protein NS2 [Homo sapiens] [BlackBoxEvent:9833031] Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9837228] Negative regulation by 'NS2 [cytosol]'
regulationReference	[RegulationReference:9837237] Negative regulation by 'NS2 [cytosol]' Human Respiratory Syncytial Virus NS2 Protein Induces Autophagy by Modulating Beclin1 Protein Stabilization and ISGylation
relatedSpecies	[Species:9717528] Human respiratory syncytial virus A
releaseDate	2023-12-06
reviewed	[InstanceEdit:9853087] Bergeron, Harrison Christopher, 2023-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9837239] R-HSA-9837231.1
structureModified	[InstanceEdit:9853033] Shamovsky, Veronica, 2023-11-09
summation	[Summation:9837229] Beclin-1 (BECN1) is an activator of autophagy. Its activity ...
(hasEvent)	[Pathway:9833110] RSV-host interactions [Homo sapiens]
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No pathways have been reviewed or authored by ISGylation of BECN1 (9837231)