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Details on Person UniProt:Q9W0V1 Pdk1
| Class:Id | ReferenceGeneProduct:98371 |
|---|---|
| _chainChangeLog | chain:1-836 added on Sat February 7 2015 |
| _displayName | UniProt:Q9W0V1 Pdk1 |
| _timestamp | 2025-02-21 19:10:36 |
| chain | chain:1-836 |
| checksum | CA274D2265D17AE2 |
| comment | FUNCTION Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBCELLULAR LOCATION Highly expressed in Malpighian tubule primordia from stage late 11 to 13. Expressed in hindgut at stage 13. After stage 14, ubiquitously expressed at low levels.DOMAIN The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.DISRUPTION PHENOTYPE Death during the second instar stage.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: 3-phosphoinositide-dependent protein kinase 1 shortName: dPDK-1 ecNumber: 2.7.11.1 alternativeName: Serine/threonine-protein kinase 61C alternativeName: dSTPK61 |
| geneName | Pdk1 Pk61C CG1210 |
| identifier | Q9W0V1 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Apoptosis ATP-binding Cytoplasm Developmental protein Differentiation Growth regulation Kinase Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Spermatogenesis Transferase |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Pdk1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PDPK1_DROME O62534 Q0E8K9 Q53XF5 Q7KVE1 Q8IHG6 Q9W0V2 Q9W0V3 |
| sequenceLength | 836 |
| species | [Species:56210] Drosophila melanogaster |
| (isoformParent) | [ReferenceIsoform:152146] UniProt:Q9W0V1-2 Pdk1 [Drosophila melanogaster] [ReferenceIsoform:152147] UniProt:Q9W0V1-3 Pdk1 [Drosophila melanogaster] [ReferenceIsoform:242297] UniProt:Q9W0V1-4 Pdk1 [Drosophila melanogaster] [ReferenceIsoform:415776] UniProt:Q9W0V1-1 Pdk1 [Drosophila melanogaster] |
| (referenceEntity) | [EntityWithAccessionedSequence:110528] PK61C [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:376967] PK61C [plasma membrane] [Drosophila melanogaster] |
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No pathways have been reviewed or authored by UniProt:Q9W0V1 Pdk1 (98371)
