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Details on Person LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)

Class:IdReaction:983709
_displayNameLYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
_doReleaseTRUE
_timestamp2018-08-09 15:35:52
authored[InstanceEdit:983698] May, B, 2010-09-28
catalystActivity[CatalystActivity:9606891] protein tyrosine kinase activity of LYN,FYN,BLK [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:983694] May, B, 2010-11-02
edited[InstanceEdit:983698] May, B, 2010-09-28
inferredFrom
input[Complex:983689] Antigen:BCR [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:983479] Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor
[LiteratureReference:983499] Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement
[LiteratureReference:1112633] Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta
[LiteratureReference:983507] Reconstitution of the B cell antigen receptor signaling components in COS cells
[LiteratureReference:1169035] Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking
[LiteratureReference:983508] Association of B cell antigen receptor with protein tyrosine kinase Lyn
[LiteratureReference:1168945] Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop
modified[InstanceEdit:1112667] May, B, 2010-12-07
[InstanceEdit:1169093] May, B, 2011-01-11
[InstanceEdit:1262951] May, B, 2011-05-05
[InstanceEdit:1977928] May, B, 2011-11-08
[InstanceEdit:2010554] May, B, 2011-11-22
[InstanceEdit:2038845] May, B, 2012-01-10
[InstanceEdit:2108989] May, B, 2012-02-11
[InstanceEdit:5251728] May, B, 2014-02-05
[InstanceEdit:9038310] May, Bruce, 2018-02-24
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9606911] May, Bruce, 2018-04-26
[InstanceEdit:9616036] May, Bruce, 2018-08-09
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9733355] Wu, Guanming, 2021-06-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameLYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
output[Complex:983691] Antigen:p-BCR [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
regulatedBy[NegativeRegulation:5690718] Negative regulation by 'PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane]'
regulationReference[RegulationReference:9641370] Negative regulation by 'PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane]' CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling
releaseDate2012-03-13
reviewed[InstanceEdit:2108988] Wienands, J, 2012-02-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2158146] R-HSA-983709.7
summation[Summation:1168939] The B cell receptor (BCR) comprises an immunoglobulin comple...
[Summation:5690671] SHP1 regulates BCR signaling by dephosphorylating CD79A/CD79...
(hasEvent)[Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [Homo sapiens]
(precedingEvent)[Reaction:983700] SYK binds the activated BCR [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775805] Update Tracker - [Reaction:983709] LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) - v78:[addSummation]
[_UpdateTracker:9779577] Update Tracker - [Reaction:983709] LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) - v65:[add_removeCatalystActivity]
[_UpdateTracker:9779872] Update Tracker - [Reaction:983709] LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) - v64:[add_removeCatalystActivity]
[_UpdateTracker:9784682] Update Tracker - [Reaction:983709] LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) - v53:[addRegulator]
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