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Details on Person SYK autophosphorylates at the activated BCR
Class:Id Reaction:983707 _displayName SYK autophosphorylates at the activated BCR _doRelease TRUE _timestamp 2019-04-08 07:02:58 authored [InstanceEdit:983698] May, B, 2010-09-28 catalystActivity [CatalystActivity:983699] protein tyrosine kinase activity of Antigen:p-BCR:p-SYK [plasma membrane] catalystActivityReference [CatalystActivityReference:9644123] protein tyrosine kinase activity of Antigen:p-BCR:p-SYK [plasma membrane] Molecular mechanism of the Syk activation switch compartment [Compartment:876] plasma membrane created [InstanceEdit:983694] May, B, 2010-11-02 edited [InstanceEdit:983698] May, B, 2010-09-28 input [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:983693] Antigen:p-BCR:SYK [plasma membrane] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:453188] Molecular mechanism of the Syk activation switch [LiteratureReference:983521] Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation [LiteratureReference:983475] Steady state kinetics of spleen tyrosine kinase investigated by a real time fluorescence assay [LiteratureReference:983496] SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma [LiteratureReference:983476] Purification and characterization of human Syk produced using a baculovirus expression system [LiteratureReference:983486] Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex [LiteratureReference:1169018] Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry [LiteratureReference:2033040] Complex phosphorylation dynamics control the composition of the Syk interactome in B cells modified [InstanceEdit:1169093] May, B, 2011-01-11 [InstanceEdit:1977928] May, B, 2011-11-08 [InstanceEdit:2010554] May, B, 2011-11-22 [InstanceEdit:2033025] May, B, 2012-01-08 [InstanceEdit:2038845] May, B, 2012-01-10 [InstanceEdit:2108989] May, B, 2012-02-11 [InstanceEdit:5251728] May, B, 2014-02-05 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9616036] May, Bruce, 2018-08-09 [InstanceEdit:9644125] May, Bruce, 2019-04-08 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name SYK autophosphorylates at the activated BCR output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:983690] Antigen:p-BCR:p-SYK [plasma membrane] [Homo sapiens] precedingEvent
regulatedBy [NegativeRegulation:5690723] Negative regulation by 'PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane]' releaseDate 2012-03-13 reviewed [InstanceEdit:2108988] Wienands, J, 2012-02-11 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:2158158] R-HSA-983707.6 summation [Summation:1168931] The SYK protein tyrosine kinase autophosphorylates at tyrosi... [Summation:5690671] SHP1 regulates BCR signaling by dephosphorylating CD79A/CD79... (hasEvent) [Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [Homo sapiens] (precedingEvent) [Reaction:983703] p-6Y-SYK phosphorylates BLNK (SLP65) [Homo sapiens] (updatedInstance) [_UpdateTracker:9775728] Update Tracker - [Reaction:983707] SYK autophosphorylates at the activated BCR - v78:[addSummation] [_UpdateTracker:9784583] Update Tracker - [Reaction:983707] SYK autophosphorylates at the activated BCR - v53:[addRegulator]
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No pathways have been reviewed or authored by SYK autophosphorylates at the activated BCR (983707)
