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Details on Person p-6Y-SYK phosphorylates BLNK (SLP65)

Class:Id	Reaction:983703
_displayName	p-6Y-SYK phosphorylates BLNK (SLP65)
_doRelease	TRUE
_timestamp	2019-04-08 07:03:20
authored	[InstanceEdit:983688] May, B, 2010-10-31
catalystActivity	[CatalystActivity:983699] protein tyrosine kinase activity of Antigen:p-BCR:p-SYK [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9644123] protein tyrosine kinase activity of Antigen:p-BCR:p-SYK [plasma membrane] Molecular mechanism of the Syk activation switch
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:983694] May, B, 2010-11-02
edited	[InstanceEdit:983688] May, B, 2010-10-31
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:983690] Antigen:p-BCR:p-SYK [plasma membrane] [Homo sapiens] [Complex:983692] BLNK:GRB2:SOS1:CIN85 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:983502] BLNK: a central linker protein in B cell activation [LiteratureReference:983470] BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins [LiteratureReference:2076210] SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation [LiteratureReference:2076256] Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha [LiteratureReference:2076240] The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways [LiteratureReference:1112635] Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation [LiteratureReference:2076207] The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85 [LiteratureReference:2076226] Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes [LiteratureReference:2101047] SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins
modified	[InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1112667] May, B, 2010-12-07 [InstanceEdit:1169093] May, B, 2011-01-11 [InstanceEdit:1977928] May, B, 2011-11-08 [InstanceEdit:2010554] May, B, 2011-11-22 [InstanceEdit:2076259] May, B, 2012-01-27 [InstanceEdit:2101046] May, B, 2012-02-08 [InstanceEdit:2108989] May, B, 2012-02-11 [InstanceEdit:5251728] May, B, 2014-02-05 [InstanceEdit:8865030] D'Eustachio, Peter, 2016-03-18 [InstanceEdit:9616036] May, Bruce, 2018-08-09 [InstanceEdit:9644125] May, Bruce, 2019-04-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-6Y-SYK phosphorylates BLNK (SLP65)
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:983687] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:983707] SYK autophosphorylates at the activated BCR [Homo sapiens] [Reaction:983700] SYK binds the activated BCR [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2108988] Wienands, J, 2012-02-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158264] R-HSA-983703.5
summation	[Summation:1168937] BLNK (SLP-65, BASH) forms a stable complex with GRB2, SOS1, ...
(hasEvent)	[Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [Homo sapiens]
(precedingEvent)	[Reaction:9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 [Homo sapiens] [Reaction:9606160] p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) [Homo sapiens]
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