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Details on Person Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)

Class:Id	BlackBoxEvent:983702
_displayName	Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)
_doRelease	TRUE
_timestamp	2018-02-24 04:28:07
authored	[InstanceEdit:983698] May, B, 2010-09-28
catalystActivity	[CatalystActivity:420385] protein tyrosine kinase activity of Fyn [cytosol] [CatalystActivity:1112663] protein tyrosine kinase activity of Lyn [cytosol] [CatalystActivity:1112659] protein tyrosine kinase activity of Tyrosine-protein kinase Blk [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:983694] May, B, 2010-11-02
edited	[InstanceEdit:983698] May, B, 2010-09-28
input	[Complex:2033050] Antigen:BCR [plasma membrane] [Mus musculus] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:983485] Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases [LiteratureReference:983508] Association of B cell antigen receptor with protein tyrosine kinase Lyn [LiteratureReference:983504] Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases [LiteratureReference:983490] Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases [LiteratureReference:983499] Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement [LiteratureReference:983507] Reconstitution of the B cell antigen receptor signaling components in COS cells [LiteratureReference:1112629] Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking [LiteratureReference:983479] Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor [LiteratureReference:1112630] Differential signaling through the Ig-alpha and Ig-beta components of the B cell antigen receptor [LiteratureReference:1112637] Immunoreceptor tyrosine-based activation motif is required to signal pathways of receptor-mediated growth arrest and apoptosis in murine B lymphoma cells [LiteratureReference:1168991] The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases [LiteratureReference:9038316] Fyn kinase is required for optimal humoral responses
modified	[InstanceEdit:1112667] May, B, 2010-12-07 [InstanceEdit:1169093] May, B, 2011-01-11 [InstanceEdit:1169459] May, B, 2011-01-19 [InstanceEdit:1977928] May, B, 2011-11-08 [InstanceEdit:2010554] May, B, 2011-11-22 [InstanceEdit:2033025] May, B, 2012-01-08 [InstanceEdit:2108989] May, B, 2012-02-11 [InstanceEdit:2157985] Matthews, L, 2012-02-29 [InstanceEdit:2876561] May, B, 2012-12-23 [InstanceEdit:9038318] May, Bruce, 2018-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:2033055] Antigen:p-BCR [plasma membrane] [Mus musculus]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2108988] Wienands, J, 2012-02-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:2158148] R-MMU-983702.3
summation	[Summation:1169493] The immunoreceptor tyrosine activation motifs (ITAMs) of Cd7...
(inferredFrom)	[Reaction:983709] LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780072] Update Tracker - [BlackBoxEvent:983702] Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b) - v64:[addLiteratureReference]
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No pathways have been reviewed or authored by Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b) (983702)