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Details on Person The Immunoglobulin of the BCR binds antigen

Class:Id	Reaction:983696
_displayName	The Immunoglobulin of the BCR binds antigen
_doRelease	TRUE
_timestamp	2018-08-09 15:36:04
authored	[InstanceEdit:983698] May, B, 2010-09-28
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:983694] May, B, 2010-11-02
edited	[InstanceEdit:983698] May, B, 2010-09-28
input	[OtherEntity:983667] Antigen [extracellular region] [Complex:983677] BCR [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1169008] Occurrence of surface IgM, IgD, and free light chains of human lymphocytes [LiteratureReference:1169010] Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes [LiteratureReference:1169061] Surface markers of human lymphocytes [LiteratureReference:983499] Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement [LiteratureReference:1169035] Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking [LiteratureReference:1168960] Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers [LiteratureReference:983507] Reconstitution of the B cell antigen receptor signaling components in COS cells [LiteratureReference:1168982] Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin [LiteratureReference:1169080] Early events in B cell activation [LiteratureReference:2033020] Molecular components of the B cell antigen receptor complex of class IgD differ partly from those of IgM [LiteratureReference:2033039] Molecular components of the B-cell antigen receptor complex of the IgM class
modified	[InstanceEdit:1169093] May, B, 2011-01-11 [InstanceEdit:1977928] May, B, 2011-11-08 [InstanceEdit:2010554] May, B, 2011-11-22 [InstanceEdit:2033025] May, B, 2012-01-08 [InstanceEdit:2038845] May, B, 2012-01-10 [InstanceEdit:2108989] May, B, 2012-02-11 [InstanceEdit:5251728] May, B, 2014-02-05 [InstanceEdit:9616036] May, Bruce, 2018-08-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The Immunoglobulin of the BCR binds antigen The Immunoglobulin of the B Cell Receptor Binds Antigen
output	[Complex:983689] Antigen:BCR [plasma membrane] [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2108988] Wienands, J, 2012-02-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158036] R-HSA-983696.3
summation	[Summation:1168933] Mature, unstimulated B cells express IgM and IgD immunoglobu...
(hasEvent)	[Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [Homo sapiens]
(precedingEvent)	[Reaction:983709] LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) [Homo sapiens] [BlackBoxEvent:9606883] CD19 is phosphorylated [Homo sapiens]
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