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Details on Person RSV dsRNA binds DDX58

Class:Id	Reaction:9836769
_displayName	RSV dsRNA binds DDX58
_doRelease	TRUE
_timestamp	2025-08-19 15:25:06
authored	[InstanceEdit:9836770] Shamovsky, Veronica, 2023-06-02
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9836770] Shamovsky, Veronica, 2023-06-02
edited	[InstanceEdit:9853010] Shamovsky, Veronica, 2023-11-09
input	[EntityWithAccessionedSequence:9836738] RSV 5'-ppp dsRNA, copy-back structured [cytosol] [Human respiratory syncytial virus A] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:168917] DDX58 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168917] DDX58 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:9837793] Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells [LiteratureReference:9837757] Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells [LiteratureReference:9837777] Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta [LiteratureReference:9837799] Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells [LiteratureReference:9837783] siRNA-Mediated Simultaneous Regulation of the Cellular Innate Immune Response and Human Respiratory Syncytial Virus Replication [LiteratureReference:9837764] Retinoic Acid-Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection
modified	[InstanceEdit:9837316] Stephan, Ralf, 2023-06-13 [InstanceEdit:9837386] Stephan, Ralf, 2023-06-14 [InstanceEdit:9837781] Shamovsky, Veronica, 2023-06-19 [InstanceEdit:9850763] Orlic-Milacic, Marija, 2023-10-12 [InstanceEdit:9851887] Orlic-Milacic, Marija, 2023-11-01 [InstanceEdit:9852855] Orlic-Milacic, Marija, 2023-11-07 [InstanceEdit:9853011] Shamovsky, Veronica, 2023-11-09 [InstanceEdit:9964027] Stephan, Ralf, 2025-08-19 [InstanceEdit:9964087] Stephan, Ralf, 2025-08-19
name	RSV dsRNA binds DDX58
output	[Complex:9836734] RSV dsRNA:DDX58:ATP [cytosol] [Homo sapiens]
relatedSpecies	[Species:9717528] Human respiratory syncytial virus A
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852848] Bergeron, Harrison Christopher, 2023-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9836810] R-HSA-9836769.2
summation	[Summation:9837308] Retinoic acid-inducible gene I (RIG-I)-like receptors (RIG-I...
(hasEvent)	[Pathway:9833110] RSV-host interactions [Homo sapiens]
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No pathways have been reviewed or authored by RSV dsRNA binds DDX58 (9836769)