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Details on Person p-PKR dimer phosphorylates PTPN2

Class:Id	Reaction:9836515
_displayName	p-PKR dimer phosphorylates PTPN2
_doRelease	TRUE
_timestamp	2025-01-29 09:17:55
authored	[InstanceEdit:9836480] Stephan, Ralf, 2023-05-29
catalystActivity	[CatalystActivity:9835964] protein kinase activity of p-EIF2AK2 dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9836512] Stephan, Ralf, 2023-05-30
edited	[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
input	[EntityWithAccessionedSequence:997292] PTPN2 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9836517] The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase
modified	[InstanceEdit:9841795] Matthews, Lisa, 2023-08-14 [InstanceEdit:9841952] Stephan, Ralf, 2023-08-16 [InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
name	p-PKR dimer phosphorylates PTPN2
output	[SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:9836510] p-PTPN2 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9833820] PKR dimer autophosphorylates [Homo sapiens] [Reaction:9833723] PKR forms a dimer [Homo sapiens]
releaseDate	2023-09-13
reviewed	[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9836519] R-HSA-9836515.2
summation	[Summation:9836511] Protein kinase R (PKR, EIF2AK2) phosphorylates the tyrosine-...
(hasEvent)	[Pathway:9833482] PKR-mediated signaling [Homo sapiens]
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No pathways have been reviewed or authored by p-PKR dimer phosphorylates PTPN2 (9836515)