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Details on Person RSV F binds TLR4:LY96:CD14

Class:Id	Reaction:9836227
_displayName	RSV F binds TLR4:LY96:CD14
_doRelease	TRUE
_timestamp	2025-08-19 15:24:57
authored	[InstanceEdit:9836254] Shamovsky, Veronica, 2023-05-24
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:830] viral capsid [Compartment:259388] virion membrane
created	[InstanceEdit:9836254] Shamovsky, Veronica, 2023-05-24
edited	[InstanceEdit:9853009] Orlic-Milacic, Marija, 2023-11-09
input	[DefinedSet:166029] CD14 [plasma membrane] [Homo sapiens] [Complex:166050] TLR4:LY96 [plasma membrane] [Homo sapiens] [Complex:9836527] hRSV A virion [extracellular region] [Human respiratory syncytial virus A]
isChimeric	FALSE
literatureReference	[LiteratureReference:9836233] Recurrent Respiratory Syncytial Virus Infection in a CD14-Deficient Patient [LiteratureReference:9836245] Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2 [LiteratureReference:181308] Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus [LiteratureReference:9837115] Host species-specific usage of the TLR4-LPS receptor complex [LiteratureReference:9837111] Role of human TLR4 in respiratory syncytial virus-induced NF-κB activation, viral entry and replication [LiteratureReference:9837100] The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus [LiteratureReference:9837101] Respiratory syncytial virus prolifically infects N2a neuronal cells, leading to TLR4 and nucleolin protein modulations and RSV F protein co-localization with TLR4 and nucleolin
modified	[InstanceEdit:9837099] Stephan, Ralf, 2023-06-09 [InstanceEdit:9837377] Stephan, Ralf, 2023-06-14 [InstanceEdit:9837386] Stephan, Ralf, 2023-06-14 [InstanceEdit:9850763] Orlic-Milacic, Marija, 2023-10-12 [InstanceEdit:9851901] Orlic-Milacic, Marija, 2023-11-02 [InstanceEdit:9852855] Orlic-Milacic, Marija, 2023-11-07 [InstanceEdit:9853011] Shamovsky, Veronica, 2023-11-09 [InstanceEdit:9964027] Stephan, Ralf, 2025-08-19 [InstanceEdit:9964087] Stephan, Ralf, 2025-08-19
name	RSV F binds TLR4:LY96:CD14
output	[Complex:9836220] TLR4:LY96:CD14:RSV A virion [plasma membrane] [Homo sapiens]
relatedSpecies	[Species:9717528] Human respiratory syncytial virus A
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852848] Bergeron, Harrison Christopher, 2023-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9836259] R-HSA-9836227.2
summation	[Summation:9836243] Respiratory syncytial virus (RSV) fusion glycoprotein (F) is...
(hasEvent)	[Pathway:9820960] Respiratory syncytial virus (RSV) attachment and entry [Homo sapiens] [Pathway:9833110] RSV-host interactions [Homo sapiens]
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No pathways have been reviewed or authored by RSV F binds TLR4:LY96:CD14 (9836227)