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Details on Person ADAR1 binds PKR

Class:IdReaction:9835944
_displayNameADAR1 binds PKR
_doReleaseTRUE
_timestamp2025-01-29 09:11:35
authored[InstanceEdit:9835455] Stephan, Ralf, 2023-05-15
compartment[Compartment:70101] cytosol
created[InstanceEdit:9835967] Stephan, Ralf, 2023-05-22
edited[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
input[Complex:9835904] ADAR1 dimer [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:83679] Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.
[LiteratureReference:9835966] A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1
[LiteratureReference:9835948] Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection
[LiteratureReference:9835943] RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR
[LiteratureReference:9835921] Adenosine deaminase ADAR1 increases gene expression at the translational level by decreasing protein kinase PKR-dependent eIF-2alpha phosphorylation
[LiteratureReference:9835880] Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses
[LiteratureReference:9835945] Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
[LiteratureReference:9841994] ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element
modified[InstanceEdit:9841795] Matthews, Lisa, 2023-08-14
[InstanceEdit:9841952] Stephan, Ralf, 2023-08-16
[InstanceEdit:9841997] Stephan, Ralf, 2023-08-16
[InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
nameADAR1 binds PKR
output[Complex:9835934] ADAR1 dimer:EIF2AK2 [cytosol] [Homo sapiens]
releaseDate2023-09-13
reviewed[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9835982] R-HSA-9835944.2
summation[Summation:9835932] Human double-stranded RNA-specific adenosine deaminase 1 (AD...
(hasEvent)[Pathway:9833482] PKR-mediated signaling [Homo sapiens]
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No pathways have been reviewed or authored by ADAR1 binds PKR (9835944)