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Details on Person Human double-stranded RNA-specific adenosine deaminase 1 (AD...
| Class:Id | Summation:9835932 |
|---|---|
| _displayName | Human double-stranded RNA-specific adenosine deaminase 1 (AD... |
| _timestamp | 2023-08-16 10:10:48 |
| created | [InstanceEdit:9835967] Stephan, Ralf, 2023-05-22 |
| modified | [InstanceEdit:9839458] Stephan, Ralf, 2023-07-06 [InstanceEdit:9841997] Stephan, Ralf, 2023-08-16 |
| text | Human double-stranded RNA-specific adenosine deaminase 1 (ADAR1) is part of the RNA editosome complex involved in editing host and viral dsRNA. It shuttles between cytosol and nucleus (Patterson & Samuel, 1995; Barraud et al, 2014). and can inhibit protein kinase R (PKR, EiF2AK2), leading to sustained protein translation. For this reason, ADAR1 shows proviral activity in some viral infections (VSV, measles), independent of its usually antiviral RNA editing function (Nie et al, 2007; Wang & Samuel, 2009; Toth et al, 2009; George et al, 2016; Chung et al, 2018). Interactions between ADAR1, PACT, and HIV Tat proteins diminish PKR activation during HIV infection. (Chukwurah et al, 2017). |
| (summation) | [Reaction:9835944] ADAR1 binds PKR [Homo sapiens] |
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No pathways have been reviewed or authored by Human double-stranded RNA-specific adenosine deaminase 1 (AD... (9835932)
