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Details on Person UniProt:O73689 zic1
| Class:Id | ReferenceGeneProduct:9835803 |
|---|---|
| _chainChangeLog | chain:1-443 for 9835803 added on Fri August 11 2023 |
| _displayName | UniProt:O73689 zic1 |
| _timestamp | 2023-11-03 15:54:16 |
| chain | chain:1-443 |
| checksum | E6E1CA481CF4C106 |
| comment | FUNCTION Transcriptional activator that induces expression of multiple genes including pax3, en2, snai2/slug, feb and a subset of wnt genes. Has multiple key roles in the regulation of neural induction and neurogenesis: acts as a neural competence factor, sensitizing the presumptive neuroectoderm to respond to subsequent neuralizing signals. Promotes both preplacodal cell fates and neural crest cell fates, two of the cell populations that arise from the neural plate border. Cooperates with pax3 in concert with wnt signaling to determine neural crest fate. Synergizes with the bmp-inhibitor noggin/nog and acts through the wnt pathway to induce expression of en2. May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.SUBCELLULAR LOCATION During early gastrula stages, widely expressed in the dorsal ectoderm. At mid-gastrula, expressed throughout the presumptive neural plate and at late gastrula, expression gradually diminishes in the dorsal midline and increases in the anterior folds. By early neurula stage, expression becomes restricted to the lateral edges of the neural plate, corresponding to the presumptive dorsal neural plate and neural crest, and in flanking ectoderm. In early tailbud stages (stages 22-23), expressed in the dorsal forebrain, midbrain and hindbrain. Subsequently expressed in the telencephalon and at the diencephalon/mesencephalon boundary. In the spinal cord, expression is restricted to the dorsal most region including the roof plate. Also expressed in the somites but not in eye vesicles. At larval stages, expressed mainly in the dorsal neural tube throughout its anteroposterior axis.DEVELOPMENTAL STAGE Expressed zygotically from the blastula stage (stage 8) and peaks in the gastrula with lower expression persisting into tailbud stages.INDUCTION By chrd/chordin, zic1, zic2, zic3 and zic5. Suppressed by bmp signaling.DOMAIN The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation (By similarity). Removal of the C-terminal regulatory domain increases activity.SIMILARITY Belongs to the GLI C2H2-type zinc-finger protein family. |
| created | [InstanceEdit:9835809] May, Bruce, 2023-05-18 |
| description | recommendedName: Zinc finger protein ZIC 1 shortName: XZic1 shortName: XlZic1 alternativeName: ODD-paired-like shortName: Xopl alternativeName: ZIC-related protein 1 shortName: ZIC-r1 alternativeName: Zinc finger protein of the cerebellum 1 |
| geneName | zic1 opl |
| identifier | O73689 |
| isSequenceChanged | FALSE |
| keyword | Activator Cytoplasm Developmental protein Differentiation DNA-binding Metal-binding Neurogenesis Nucleus Reference proteome Repeat Transcription Transcription regulation Wnt signaling pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | zic1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ZIC1_XENLA O57461 |
| sequenceLength | 443 |
| species | [Species:51320] Xenopus laevis |
| (referenceEntity) | [EntityWithAccessionedSequence:9835808] zic1 [nucleoplasm] [Xenopus laevis] |
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No pathways have been reviewed or authored by UniProt:O73689 zic1 (9835803)
