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Details on Person UniProt:Q645N4 pax3-a

Class:Id	ReferenceGeneProduct:9835798
_chainChangeLog	chain:1-484 for 9835798 added on Fri August 11 2023
_displayName	UniProt:Q645N4 pax3-a
_timestamp	2023-11-03 15:20:16
chain	chain:1-484
checksum	F8823DFA2EEB3C71
comment	FUNCTION Probable transcription factor. Promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border. Acts downstream of msx1 to induce the neural crest, cooperating with zic1 and mediating signals from both the wnt and fgf8 signaling pathways. Induction of hatching gland cell fate is independent of zic1.SUBCELLULAR LOCATION Expressed in the dorsolateral ectoderm during early and mid-gastrula stages. At late-gastrula and neurula stages, expressed in the lateral neural plate, becoming progressively refined to the neural folds during convergence and extension. Expression is also restricted in the A/P axis, extending into the midbrain but excluded from the forebrain.INDUCTION By wnt-signaling from the posterior mesoderm.SIMILARITY Belongs to the paired homeobox family.
created	[InstanceEdit:9835809] May, Bruce, 2023-05-18
description	recommendedName: Paired box protein Pax-3-A shortName: xPax3-A alternativeName: Paired-domain transcription factor Pax3-A
geneName	pax3-a pax3 pax3A
identifier	Q645N4
isSequenceChanged	FALSE
keyword	Alternative splicing Developmental protein Differentiation DNA-binding Homeobox Neurogenesis Nucleus Paired box Reference proteome Transcription Transcription regulation Wnt signaling pathway
modified	[InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name	pax3-a
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	PAX3A_XENLA Q32NL3 Q5UCU1
sequenceLength	484
species	[Species:51320] Xenopus laevis
(isoformParent)	[ReferenceIsoform:9835796] UniProt:Q645N4-1 pax3-a [Xenopus laevis] [ReferenceIsoform:9835811] UniProt:Q645N4-2 pax3-a [Xenopus laevis]
(referenceEntity)	[EntityWithAccessionedSequence:9835804] pax3-a [nucleoplasm] [Xenopus laevis]
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No pathways have been reviewed or authored by UniProt:Q645N4 pax3-a (9835798)