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Details on Person PINK1 phosphorylates Ub on MOM proteins

Class:Id	Reaction:9834945
_displayName	PINK1 phosphorylates Ub on MOM proteins
_doRelease	TRUE
_timestamp	2024-05-21 00:23:25
authored	[InstanceEdit:9834059] Shamovsky, Veronica, 2023-05-05
catalystActivity	[CatalystActivity:9834937] protein serine/threonine kinase activity of p-S228,S402-PINK1:p-S228,S402-PINK1 [mitochondrial outer membrane]
catalystActivityReference	[CatalystActivityReference:9839813] protein serine/threonine kinase activity of p-S228,S402-PINK1:p-S228,S402-PINK1 [mitochondrial outer membrane] Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9834968] Shamovsky, Veronica, 2023-05-11
edited	[InstanceEdit:9910572] Shamovsky, Veronica, 2024-05-15
input	[SimpleEntity:113592] ATP [cytosol] [CandidateSet:9835003] Ub-MOM proteins [mitochondrial outer membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9851291] Matthews, Lisa, 2023-10-18 [InstanceEdit:9852857] Gillespie, Marc E, 2023-11-07
isChimeric	FALSE
literatureReference	[LiteratureReference:9839449] PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity [LiteratureReference:9838786] Ubiquitin is phosphorylated by PINK1 to activate parkin [LiteratureReference:9838775] Structural basis for feedforward control in the PINK1/Parkin pathway [LiteratureReference:9838789] Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering [LiteratureReference:9838797] Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy
modified	[InstanceEdit:9838783] Shamovsky, Veronica, 2023-06-26 [InstanceEdit:9839825] Shamovsky, Veronica, 2023-07-10 [InstanceEdit:9910579] Shamovsky, Veronica, 2024-05-15 [InstanceEdit:9910801] Shamovsky, Veronica, 2024-05-21
name	PINK1 phosphorylates Ub on MOM proteins PINK1 phosphorylates Ub on mitochondrial proteins
output	[SimpleEntity:29370] ADP [cytosol] [CandidateSet:9834977] p-S65-Ub:MOM proteins [mitochondrial outer membrane] [Homo sapiens]
precedingEvent	[Reaction:9834076] PINK1 is autophosphorylated [Homo sapiens] [Reaction:5205672] Uncleaved Pink1 accumulates in damaged mitochondria [Homo sapiens]
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9835073] R-HSA-9834945.1
summation	[Summation:9838794] Upon mitochondrial damage, activated PINK1 accumulates at th...
(hasEvent)	[Pathway:5205685] PINK1-PRKN Mediated Mitophagy [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9835009] PRKN binds p-S-Ub:MOM proteins [Homo sapiens]
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