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Details on Person p-PRKRA dimer binds PKR

Class:IdReaction:9834821
_displayNamep-PRKRA dimer binds PKR
_doReleaseTRUE
_timestamp2025-01-29 09:18:40
authored[InstanceEdit:9833966] Stephan, Ralf, 2023-05-05
compartment[Compartment:70101] cytosol
created[InstanceEdit:9834828] Stephan, Ralf, 2023-05-10
edited[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
input[Complex:9834844] p-PRKRA dimer [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9834816] Modular structure of PACT: distinct domains for binding and activating PKR
[LiteratureReference:9834802] Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis
[LiteratureReference:9834832] PACT, a protein activator of the interferon-induced protein kinase, PKR
[LiteratureReference:9834779] Contribution of the two dsRBM motifs to the double-stranded RNA binding and protein interactions of PACT
[LiteratureReference:9841963] The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)
modified[InstanceEdit:9834874] Stephan, Ralf, 2023-05-10
[InstanceEdit:9835124] Stephan, Ralf, 2023-05-11
[InstanceEdit:9841795] Matthews, Lisa, 2023-08-14
[InstanceEdit:9841952] Stephan, Ralf, 2023-08-16
[InstanceEdit:9841967] Stephan, Ralf, 2023-08-16
[InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
namep-PRKRA dimer binds PKR
output[Complex:9834815] p-PRKRA:EIF2AK2 dimer [cytosol] [Homo sapiens]
releaseDate2023-09-13
reviewed[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9834859] R-HSA-9834821.2
structureModified[InstanceEdit:9834874] Stephan, Ralf, 2023-05-10
summation[Summation:9834785] Binding of interferon-inducible double-stranded RNA-dependen...
(hasEvent)[Pathway:9833482] PKR-mediated signaling [Homo sapiens]
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