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| Class:Id | Summation:9834781 |
|---|---|
| _displayName | SUMO (Small Ubiquitin-like Modifier) proteins 1 and 2 (SUMO1... |
| _timestamp | 2023-05-10 13:23:26 |
| created | [InstanceEdit:9834828] Stephan, Ralf, 2023-05-10 |
| text | SUMO (Small Ubiquitin-like Modifier) proteins 1 and 2 (SUMO1, SUMO2) interact with protein kinase R (PKR, EIF2AK2) in both a covalent and non-covalent manner. SUMO E3 ligases can modify PKR on lysine residues 60, 150, and 440. Non-covalent interaction (complexation) of SUMO1 with PKR facilitates this covalent SUMOylation with subsequent autophosphorylation of PKR. However, as soon as lysine-162 is autophosphorylated, any complexation of SUMO1 is abandoned (de la Cruz-Herrera et al, 2014; de la Cruz-Herrera et al, 2017). |
| (summation) | [BlackBoxEvent:9834809] SUMOylation of PKR [Homo sapiens] |
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