Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Replication of the negative sense genomic RNA of the human r...
| Class:Id | Summation:9834726 |
|---|---|
| _displayName | Replication of the negative sense genomic RNA of the human r... |
| _timestamp | 2023-11-07 23:26:27 |
| created | [InstanceEdit:9834755] Orlic-Milacic, Marija, 2023-05-10 |
| modified | [InstanceEdit:9838754] Orlic-Milacic, Marija, 2023-06-26 [InstanceEdit:9839741] Stephan, Ralf, 2023-07-10 [InstanceEdit:9852921] Orlic-Milacic, Marija, 2023-11-07 [InstanceEdit:9852929] Orlic-Milacic, Marija, 2023-11-07 |
| text | Replication of the negative sense genomic RNA of the human respiratory syncytial virus (RSV) occurs through the positive sense intermediate, also known as antigenomic RNA. RNA synthesis is performed by the RNA-dependent RNA polymerase (RdRP) complex composed at a minimum of the L protein, which is the catalytic subunit of RdRP, and P protein. Protein M2-1 that acts as a processivity factor is described as a consitutive RdRP subunit by some and as an accessory RdRP subunit by other studies (reviewed in Fearns and Deval 2016). Replication of both genomic and antigenomic RNA depends on encapsidation by protein N, which has regions that interact with both protein P and protein L. Encapsidation protects genomic and antigenomic RNA from degradation as these RNAs do not possess the 5' cap and the poly(A) tail. Replication occurs after primary transcription. Accumulation of the protein M2-2 is responsible for the shift of RNA synthesis from transcription to replication through a mechanism that has not been fully elucidated (For review, refer to Collins and Melero 2011, Battles and McLellan 2019). |
| (summation) | [Pathway:9834752] Respiratory syncytial virus genome replication [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Replication of the negative sense genomic RNA of the human r... (9834726)
