Query author contributions in Reactome
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Details on Person On viral infection PCB2 binds MAVS (IPS-1) and recruits the ...
| Class:Id | Summation:983444 |
|---|---|
| _displayName | On viral infection PCB2 binds MAVS (IPS-1) and recruits the ... |
| _timestamp | 2024-11-05 11:22:05 |
| created | [InstanceEdit:983447] Garapati, P V, 2010-11-01 |
| literatureReference | [LiteratureReference:983448] PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 |
| modified | [InstanceEdit:9927237] Shamovsky, Veronica, 2024-11-05 |
| text | On viral infection PCB2 binds MAVS (IPS-1) and recruits the HECT domain-containing E3 ligase ITCH (AIP4). ITCH catalyses K48-polyubiquitination and degradation of MAVS. PCBP2 overexpression enhanced the interaction between MAVS and ITCH (AIP4) and led to more degradation of MAVS. MAVS (IPS-1) regulation is very important in preventing excessive harmful immune responses. |
| (summation) | [Reaction:990526] Recruitment of ITCH and K48 ubiquitination of MAVS [Homo sapiens] |
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No pathways have been reviewed or authored by On viral infection PCB2 binds MAVS (IPS-1) and recruits the ... (983444)
