Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P13217 norpA
| Class:Id | ReferenceGeneProduct:98342 |
|---|---|
| _chainChangeLog | chain:1-1095 added on Fri February 6 2015 |
| _displayName | UniProt:P13217 norpA |
| _timestamp | 2023-11-03 15:39:03 |
| chain | chain:1-1095 |
| checksum | CC712ABF9B065BB6 |
| comment | FUNCTION The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)SUBUNIT Interacts with inaD.INTERACTION Abundantly expressed in the adult retina.DISRUPTION PHENOTYPE Flies have no photoreceptor potential, their eyes lack phospholipase C (PLC) activity and they are completely blind.CAUTION 3D structural studies were performed with a synthetic heptapeptide that contained Cys, corresponding to position 1094, therefore the detected disulfide bridge is an artifact. |
| description | recommendedName: fullName evidence="12"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ecNumber evidence="2"3.1.4.11 alternativeName: fullName evidence="11 14"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta alternativeName: fullName evidence="10"No receptor potential A protein alternativeName: fullName evidence="12"Phosphoinositide phospholipase C alternativeName: fullName evidence="12"Phosphoinositide phospholipase C-beta |
| geneName | norpA PLC-beta CG3620 |
| identifier | P13217 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Hydrolase Lipid degradation Lipid metabolism Reference proteome Sensory transduction Transducer Vision |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | norpA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PIPA_DROME A4V3Y2 Q59E70 Q86P93 Q9U4G4 Q9W4K9 |
| sequenceLength | 1095 |
| species | [Species:56210] Drosophila melanogaster |
| (isoformParent) | [ReferenceIsoform:356206] UniProt:P13217-2 norpA [Drosophila melanogaster] [ReferenceIsoform:402908] UniProt:P13217-1 norpA [Drosophila melanogaster] |
| (referenceEntity) | [EntityWithAccessionedSequence:427121] NORPA [rhabdomere membrane] [Drosophila melanogaster] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P13217 norpA (98342)
